Traumatic spinal cord injury: an overview of pathophysiology, models and acute injury mechanisms

A Alizadeh, SM Dyck, S Karimi-Abdolrezaee - Frontiers in neurology, 2019 - frontiersin.org
Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Spinal cord repair: advances in biology and technology

G Courtine, MV Sofroniew - Nature medicine, 2019 - nature.com
Individuals with spinal cord injury (SCI) can face decades with permanent disabilities.
Advances in clinical management have decreased morbidity and improved outcomes, but …

Characterizing natural recovery after traumatic spinal cord injury

S Kirshblum, B Snider, F Eren, J Guest - Journal of neurotrauma, 2021 - liebertpub.com
The predominant tool used to predict outcomes after traumatic spinal cord injury (SCI) is the
International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI), in …

Traumatic spinal cord injury

CS Ahuja, JR Wilson, S Nori, M Kotter… - Nature reviews Disease …, 2017 - nature.com
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

First-in-human clinical trial of transplantation of iPSC-derived NS/PCs in subacute complete spinal cord injury: Study protocol

K Sugai, M Sumida, T Shofuda, R Yamaguchi… - Regenerative …, 2021 - Elsevier
Introduction Our group has conducted extensive basic and preclinical studies of the use of
human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) …

The neuroanatomical–functional paradox in spinal cord injury

K Fouad, PG Popovich, MA Kopp… - Nature Reviews …, 2021 - nature.com
Although lesion size is widely considered to be the most reliable predictor of outcome after
CNS injury, lesions of comparable size can produce vastly different magnitudes of functional …

Long-term training with a brain-machine interface-based gait protocol induces partial neurological recovery in paraplegic patients

ARC Donati, S Shokur, E Morya, DSF Campos… - Scientific reports, 2016 - nature.com
Brain-machine interfaces (BMIs) provide a new assistive strategy aimed at restoring mobility
in severely paralyzed patients. Yet, no study in animals or in human subjects has indicated …

A clinical practice guideline for the management of acute spinal cord injury: introduction, rationale, and scope

MG Fehlings, LA Tetreault, JR Wilson… - Global spine …, 2017 - journals.sagepub.com
Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal
sensory, motor, or autonomic function and ultimately affects a patient's physical …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …