Circadian rhythms and sleep are fundamental biological processes integral to human
health. Their disruption is associated with detrimental physiological consequences …

Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the
lateral hypothalamus and send axons to numerous regions throughout the central nervous …

Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …

Narcolepsy is a disabling sleep disorder affecting humans and animals. It is characterized
by daytime sleepiness, cataplexy, and striking transitions from wakefulness into rapid eye …

Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt)(orexin)
precursor or Hcrt receptor genes. In contrast to these animal models, most human …

We explored the role of hypocretins in human narcolepsy through histopathology of six
narcolepsy brains and mutation screening of Hcrt, Hcrtr1 and Hcrtr2 in 74 patients of various …

The orexin-A/hypocretin-1 and orexin-B/hypocretin-2 are neuropeptides synthesized by a
cluster of neurons in the lateral hypothalamus and perifornical area. Orexin neurons receive …

Hypocretin (orexin) deficiency in human narcolepsy - The Lancet Skip to Main Content
Advertisement The Lancet Journal Submit Article Log in Register Log in Submit Article Log …