Highlights•Mechanisms of nuclear size and shape regulation.•Cell cycle events that
influence nuclear morphology.•Nuclear morphology, chromatin organization, and gene …

One of the characteristics of eukaryotic cells is their structural plasticity associated with the
ability to carry out a broad range of complex functions, both autonomously and as …

Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by
linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from …

Cell size varies greatly among different cell types and organisms, especially during early
development when cell division is rapid with little overall growth. A fundamental question is …

Cell nuclei are physically integrated with the cytoskeleton through the linker of
nucleoskeleton and cytoskeleton (LINC) complex, a structure that spans the nuclear …

The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic
reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear …

Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that
are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type …

Understanding the protein composition of the inner nuclear membrane (INM) is fundamental
to elucidating its role in normal nuclear function and in disease; however, few tools exist to …

Centrosomes are a functionally conserved feature of eukaryotic cells that play an important
role in cell division. The conserved γ-tubulin complex organizes spindle and astral …