Class A PBPs: It is time to rethink traditional paradigms

D Straume, KW Piechowiak, M Kjos… - Molecular …, 2021 - Wiley Online Library
Until recently, class A penicillin‐binding proteins (aPBPs) were the only enzymes known to
catalyze glycan chain polymerization from lipid II in bacteria. Hence, the discovery of two …

Toward a mechanistic understanding of bacterial rod shape formation and regulation

EC Garner - Annual Review of Cell and Developmental Biology, 2021 - annualreviews.org
One of the most common bacterial shapes is a rod, yet we have a limited understanding of
how this simple shape is constructed. While only six proteins are required for rod shape, we …

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in Bacillus subtilis cell division

KD Whitley, C Jukes, N Tregidgo, E Karinou… - Nature …, 2021 - nature.com
Despite the central role of division in bacterial physiology, how division proteins work
together as a nanoscale machine to divide the cell remains poorly understood. Cell division …

Roles of RodZ and class A PBP1b in the assembly and regulation of the peripheral peptidoglycan elongasome in ovoid‐shaped cells of Streptococcus pneumoniae …

MM Lamanna, I Manzoor, M Joseph, ZA Ye… - Molecular …, 2022 - Wiley Online Library
RodZ of rod‐shaped bacteria functions to link MreB filaments to the Rod peptidoglycan (PG)
synthase complex that moves circumferentially perpendicular to the long cell axis, creating …

MurA escape mutations uncouple peptidoglycan biosynthesis from PrkA signaling

S Wamp, P Rothe, D Stern, G Holland, J Döhling… - PLoS …, 2022 - journals.plos.org
Gram-positive bacteria are protected by a thick mesh of peptidoglycan (PG) completely
engulfing their cells. This PG network is the main component of the bacterial cell wall, it …

Metabolic Control of Cell Elongation and Cell Division in Bacillus subtilis

A Galinier, E Foulquier, F Pompeo - Frontiers in Microbiology, 2021 - frontiersin.org
To survive and adapt to changing nutritional conditions, bacteria must rapidly modulate cell
cycle processes, such as doubling time or cell size. Recent data have revealed that cellular …

The role of cell-envelope synthesis for envelope growth and cytoplasmic density in Bacillus subtilis

Y Kitahara, ER Oldewurtel, S Wilson, Y Sun… - PNAS …, 2022 - academic.oup.com
All cells must increase their volumes in response to biomass growth to maintain intracellular
mass density within physiologically permissive bounds. Here, we investigate the regulation …

Cell-envelope synthesis is required for surface-to-mass coupling, which determines dry-mass density in Bacillus subtilis

Y Kitahara, ER Oldewurtel, S Wilson, Y Sun, EC Garner… - bioRxiv, 2021 - biorxiv.org
Cells must increase their volumes in response to biomass growth to maintain intracellular
mass density, the ratio of dry mass to cell volume, within physiologically permissive bounds …