[PDF][PDF] The unique biology of germinal center B cells
Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies
required for protective immunity. The unique biology of GC B cells involves iterative rounds …
required for protective immunity. The unique biology of GC B cells involves iterative rounds …
New insights into B cells as antigen presenting cells
Highlights•The MHCII antigen presentation pathway has unique features in B cells.•The
MHCII antigen presentation pathway is regulated differently in different B cell subsets.•B cell …
MHCII antigen presentation pathway is regulated differently in different B cell subsets.•B cell …
[PDF][PDF] Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance
Conventional immunization strategies will likely be insufficient for the development of a
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of …
[PDF][PDF] Continuous germinal center invasion contributes to the diversity of the immune response
Antibody responses are characterized by increasing affinity and diversity over time. Affinity
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …
maturation occurs in germinal centers by a mechanism that involves repeated cycles of …
[PDF][PDF] Clonal replacement sustains long-lived germinal centers primed by respiratory viruses
RVH de Carvalho, J Ersching, A Barbulescu, A Hobbs… - Cell, 2023 - cell.com
Germinal centers (GCs) form in secondary lymphoid organs in response to infection and
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
immunization and are the source of affinity-matured B cells. The duration of GC reactions …
[HTML][HTML] Control of germinal center responses by T-follicular regulatory cells
Regulatory T-cells (Treg cells), expressing the transcription factor Foxp3, have an essential
role in the control of immune homeostasis. In order to control diverse types of immune …
role in the control of immune homeostasis. In order to control diverse types of immune …
[HTML][HTML] Positive selection in the light zone of germinal centers
R Nakagawa, DP Calado - Frontiers in Immunology, 2021 - frontiersin.org
Germinal centers (GCs) are essential sites for the production of high-affinity antibody
secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of …
secreting plasma cells (PCs) and memory-B cells (MBCs), which form the framework of …
Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC),
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and …
perhaps by increased acquisition of antigen for presentation to follicular helper T cells and …
[HTML][HTML] Vaccine adjuvants differentially affect kinetics of antibody and germinal center responses
GK Pedersen, K Wørzner, P Andersen… - Frontiers in …, 2020 - frontiersin.org
Aluminum salts and squalene based oil-in-water emulsions (SE) are widely used adjuvants
in licensed vaccines, yet their mechanisms are not fully known. Here we report that induction …
in licensed vaccines, yet their mechanisms are not fully known. Here we report that induction …
[PDF][PDF] Antigen presentation dynamics shape the antibody response to variants like SARS-CoV-2 Omicron after multiple vaccinations with the original strain
The Omicron variant of SARS-CoV-2 is not effectively neutralized by most antibodies elicited
by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing …
by two doses of mRNA vaccines, but a third dose increases anti-Omicron neutralizing …