[HTML][HTML] Autophagy: an important target for natural products in the treatment of bone metabolic diseases
Z Li, D Li, H Su, H Xue, G Tan, Z Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
Bone homeostasis depends on a precise dynamic balance between bone resorption and
bone formation, involving a series of complex and highly regulated steps. Any imbalance in …
bone formation, involving a series of complex and highly regulated steps. Any imbalance in …
LAMP2A regulates the balance of mesenchymal stem cell adipo-osteogenesis via the Wnt/β-catenin/GSK3β signaling pathway
Y Wang, K Hang, L Ying, J Wu, X Wu, W Zhang… - Journal of Molecular …, 2023 - Springer
Chaperone-mediated autophagy (CMA) plays multiple roles in cell metabolism. We found
that lysosome-associated membrane protein type 2A (LAMP2A), a crucial protein of CMA …
that lysosome-associated membrane protein type 2A (LAMP2A), a crucial protein of CMA …
Novel methods for the generation of genetically engineered animal models
A Cassidy, M Onal, S Pelletier - Bone, 2023 - Elsevier
Genetically modified mouse models have shaped our understanding of biological systems in
both physiological and pathological conditions. For decades, mouse genome engineering …
both physiological and pathological conditions. For decades, mouse genome engineering …
[HTML][HTML] CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system
DJ Laster, NS Akel, JA Hendrixson, A James… - iScience, 2023 - cell.com
Cre-mediated recombination is frequently used for cell type-specific loss of function (LOF)
studies. A major limitation of this system is recombination in unwanted cell types. CRISPR …
studies. A major limitation of this system is recombination in unwanted cell types. CRISPR …
Intrinsic contractile dysfunction due to impaired sarcoplasmic reticulum Ca2+ release in compensatory hypertrophied muscle fibers following synergist ablation
N Tokuda, D Watanabe, A Naito… - … of Physiology-Cell …, 2023 - journals.physiology.org
Synergist ablation (SA) is an experimental procedure for the induction of hypertrophy.
However, SA causes a decrease in specific force (ie, force per cross-sectional area), likely …
However, SA causes a decrease in specific force (ie, force per cross-sectional area), likely …
[HTML][HTML] Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
JA Hendrixson, A James, NS Akel, DJ Laster… - FASEB …, 2024 - ncbi.nlm.nih.gov
Chaperone‐mediated autophagy (CMA) is a lysosome‐dependent degradation pathway
that eliminates proteins that are damaged, partially unfolded, or targeted for selective …
that eliminates proteins that are damaged, partially unfolded, or targeted for selective …
Chaperone‐mediated autophagy protects the bone formation from excessive inflammation through PI3K/AKT/GSK3β/β‐catenin pathway
K Hang, YB Wang, JW Bai, ZX Wang, WL Wu… - The FASEB …, 2024 - Wiley Online Library
Multiple regulatory mechanisms are in place to ensure the normal processes of bone
metabolism, encompassing both bone formation and absorption. This study has identified …
metabolism, encompassing both bone formation and absorption. This study has identified …
Impact of tyrosine kinase inhibitors and bone morphogenetic proteins on persistent leukemic stem cell dormancy in Chronic Myeloid Leukemia patients at remission
K Arizkane - 2022 - theses.hal.science
Despite the therapeutic progress of Chronic Myeloid Leukemia (CML) due to the Tyrosine
Kinase Inhibitors (TKIs) that targets specifically BCR-ABL kinase, TKI treatment is not yet …
Kinase Inhibitors (TKIs) that targets specifically BCR-ABL kinase, TKI treatment is not yet …