Effects of pH on an IDP conformational ensemble explored by molecular dynamics simulation
RJ Lindsay, RA Mansbach, S Gnanakaran, T Shen - Biophysical chemistry, 2021 - Elsevier
The conformational ensemble of intrinsically disordered proteins, such as α-synuclein, are
responsible for their function and malfunction. Misfolding of α-synuclein can lead to …
responsible for their function and malfunction. Misfolding of α-synuclein can lead to …
Robustness of density of low-frequency states in amorphous solids
Low-frequency quasilocalized modes of amorphous glass appear to exhibit universal
density of states, depending on the frequencies as D (ω)∼ ω 4. To date, various models of …
density of states, depending on the frequencies as D (ω)∼ ω 4. To date, various models of …
[HTML][HTML] Node features of chromosome structure networks and their connections to genome annotation
The 3D conformations of chromosomes can encode biological significance, and the
implications of such structures have been increasingly appreciated recently. Certain …
implications of such structures have been increasingly appreciated recently. Certain …
Novel Covalent Modifier-Induced Local Conformational Changes within the Intrinsically Disordered Region of the Androgen Receptor
MT Harnish, D Lopez, CT Morrison, R Narayanan… - Biology, 2023 - mdpi.com
Simple Summary The androgen receptor (AR) is an important protein involved in sensing
hormones. The over-activation of a class of AR can lead to cellular dysfunction and diseases …
hormones. The over-activation of a class of AR can lead to cellular dysfunction and diseases …
Inferring chromosome radial organization from Hi-C data
Background The nonrandom radial organization of eukaryotic chromosome territories (CTs)
inside the nucleus plays an important role in nuclear functional compartmentalization …
inside the nucleus plays an important role in nuclear functional compartmentalization …
Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ
B Pham, Z Cheng, D Lopez, RJ Lindsay… - Frontiers in Molecular …, 2022 - frontiersin.org
The receptor RORγ belongs to the nuclear receptor superfamily that senses small signaling
molecules and regulates at the gene transcription level. Since RORγ has a high basal …
molecules and regulates at the gene transcription level. Since RORγ has a high basal …
MODULATION OF PROTEIN DYNAMICS BY LIGAND BINDING AND SOLVENT COMPOSITION
RJ Lindsay - 2021 - trace.tennessee.edu
Many proteins undergo conformational switching in order to perform their cellular functions.
A multitude of factors may shift the energy landscape and alter protein dynamics with varying …
A multitude of factors may shift the energy landscape and alter protein dynamics with varying …