Obesity is an epidemic worldwide and the obese people suffer from a range of respiratory
complications including fibrotic changes in the lung. The influence of obesity on the lung is …

Dedicator of cytokinesis 2 (DOCK2) can activate the downstream small G protein Rac and
regulate cytoskeletal reorganization. DOCK2 is essential for critical physiological processes …

Pulmonary fibrosis (PF) is an interstitial lung disease characterized by the destruction of the
pulmonary parenchyma caused by excessive extracellular matrix deposition. Despite the …

Adipose tissue has functions beyond its principal functions in energy storage, including
endocrine and immune functions. When faced with a surplus of energy, the functions of …

Background Obesity has been identified as a risk factor for acute lung injury/acute
respiratory distress syndrome (ALI/ARDS). However, the underlying mechanisms remain …

Idiopathic pulmonary fibrosis (IPF) is the most common chronic interstitial lung disease and
is characterized by progressive scarring of the lung. Transforming growth factor-β (TGF-β) …

Idiopathic pulmonary fibrosis (IPF) constitutes a long-term disease with a complex
pathophysiology composed of multiple molecular actors that lead to the deposition of …

Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and
survival rate of patients. This study aimed to determine the effect and regulation mechanism …

Renal fibrosis is the most important feature of the progression of chronic kidney disease
(CKD), and epithelial–mesenchymal transition (EMT) plays an important role in renal …

Background Individuals with obesity have higher level of circulating succinate, which acts as
a signaling factor that initiates inflammation. It is obscure whether succinate and succinate …