Small cell lung cancer: Subtypes and therapeutic implications
WZ Wang, A Shulman, JM Amann, DP Carbone… - Seminars in cancer …, 2022 - Elsevier
Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …
YAP and TAZ: monocorial and bicorial transcriptional co-activators in human cancers
FL Sardo, V Canu, M Maugeri-Saccà, S Strano… - … et Biophysica Acta (BBA …, 2022 - Elsevier
The transcriptional regulators YAP and TAZ are involved in numerous physiological
processes including organ development, growth, immunity and tissue regeneration. YAP …
processes including organ development, growth, immunity and tissue regeneration. YAP …
[HTML][HTML] Targeting mechanosensitive Piezo1 alleviated renal fibrosis through p38MAPK-YAP pathway
Y Fu, P Wan, J Zhang, X Li, J Xing, Y Zou… - Frontiers in Cell and …, 2021 - frontiersin.org
Renal fibrosis is the most common pathological manifestation of a wide variety of chronic
kidney disease. Increased extracellular matrix (ECM) secretion and enhanced …
kidney disease. Increased extracellular matrix (ECM) secretion and enhanced …
[HTML][HTML] YAP1 synergize with YY1 transcriptional co-repress DUSP1 to induce osimertinib resistant by activating the EGFR/MAPK pathway and abrogating autophagy …
Y Ning, H Zheng, Y Yang, H Zang, W Wang… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
YAP1 is a well-known core effector of the Hippo pathway in tumors, but its potential role in
osimertinib resistance remained unexplored. Our study provides evidence that YAP1 acts as …
osimertinib resistance remained unexplored. Our study provides evidence that YAP1 acts as …
[HTML][HTML] CircRNA_100395 carried by exosomes from adipose-derived mesenchymal stem cells inhibits the malignant transformation of non-small cell lung carcinoma …
C Zhang, J Cao, W Lv, H Mou - Frontiers in cell and developmental …, 2021 - frontiersin.org
Objective: The specific purpose of this study is to investigate the impact exosomes from
adipose-derived mesenchymal stem cell (AMSC) has on non-small cell lung carcinoma …
adipose-derived mesenchymal stem cell (AMSC) has on non-small cell lung carcinoma …
The Hippo pathway: a master regulatory network important in cancer
Q Liu, X Liu, G Song - Cells, 2021 - mdpi.com
The Hippo pathway is pervasively activated and has been well recognized to play critical
roles in human cancer. The deregulation of Hippo signaling involved in cancer …
roles in human cancer. The deregulation of Hippo signaling involved in cancer …
Integrated network pharmacology, molecular docking, molecular simulation, and in vitro validation revealed the bioactive components in soy-fermented food products …
Globally, lung cancer remains one of the leading causes of cancer-related mortality,
warranting the exploration of novel and effective therapeutic approaches. Soy-fermented …
warranting the exploration of novel and effective therapeutic approaches. Soy-fermented …
Inhibition effect of oxyepiberberine isolated from Coptis chinensis franch. On non-small cell lung cancer based on a network pharmacology approach and …
Y Zhang, Y Yao, Y Fu, Z Yuan, X Wu, T Wang… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance As an important Chinese herb, Coptis chinensis
Franch.(Huanglian, HL) has a long history of usage for clearing heat, eliminating dampness …
Franch.(Huanglian, HL) has a long history of usage for clearing heat, eliminating dampness …
[PDF][PDF] Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity
Y Guo, X Lu, Y Chen, G Clark, J Trent, M Cuatrecasas… - Cell Reports, 2022 - cell.com
Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and is initiated by
mesenchyme-driving transcription factors and actin cytoskeletal assembly. We show a …
mesenchyme-driving transcription factors and actin cytoskeletal assembly. We show a …
Inhibition of TRPC6 suppressed TGFβ-induced fibroblast-myofibroblast transdifferentiation in renal interstitial NRK-49F cells
S Jiang, L Gu, Y Hu, Y Ren, Z Yang, C Chai… - Experimental Cell …, 2022 - Elsevier
Renal fibrosis is a global health concern with limited curative treatment. Canonical transient
receptor potential channel 6 (TRPC6), a nonselective cation channel, has been shown to …
receptor potential channel 6 (TRPC6), a nonselective cation channel, has been shown to …