Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

Background Chronic pancreatitis (CP) is a progressive inflammatory disorder currently
diagnosed by morphologic features. In contrast, an accurate diagnosis of Early CP is not …

Lipoprotein disorder is a common feature of chronic pancreatitis (CP); however, the
relationship between lipoprotein disorder and pancreatic fibrotic environment is unclear …

Inflammatory and fibrotic events that drive chronic pancreatitis (CP) are likely orchestrated
via signaling of soluble cytokines and chemokines systemically and within the pancreas …

Objectives The aim of this study was to investigate the role of P2X7R (purinergic 2X7
receptor) and NLRP3 (NACHT, LRR, and PYD domains–containing protein 3) …

Chronic pancreatitis (CP) is an utmost complex disease that is pathogenetically linked to
pancreas‐intrinsic (eg, duct obstruction), environmental‐toxic (eg, alcohol, smoking), and …

Pancreatic ductal adenocarcinoma (PDAC) is often associated with a poor prognosis due to
silent onset, resistance to therapies, and rapid spreading. Most patients are ineligible for …

There is a need for short-term, reliable and reproducible animal model of chronic
pancreatitis (CP) in small animals like mice. This study was aimed to establish the 9 …

Background Acute pancreatitis (AP), an inflammatory condition of pancreas, destructs the
exocrine cells by releasing various pro-inflammatory cytokines that activates the stellate …

Chemical agents can cause cancer in animals by damaging their DNA, mutating their genes,
and modifying their epigenetic signatures. Carcinogen-induced preclinical cancer models …