Accelerated development of novel CRISPR/Cas9-based genome editing techniques
provides a feasible approach to introduce a variety of precise modifications in the …

Swine is biologically one of the most relevant large animal models for biomedical research.
With its use as food animal that can be exploited as a free cell and tissue source for research …

As a new genetic engineering technology, gene editing can precisely modify the specific
gene sequence of the organism's genome. In the last 10 years, with the rapid development …

Swine hepatitis E virus (swine HEV) belongs to the species Orthohepevirus A within the
genus Orthohepevirus in the family Hepeviridae. Four different genotypes of swine HEV …

Hepatitis E virus (HEV) causes adverse clinical outcomes in pregnant women, but the
underlying mechanisms remain poorly understood. To delineate the mechanisms of …

Historically, genetic engineering in livestock proved to be challenging. Without stable
embryonic stem cell lines to utilize, somatic cell nuclear transfer (SCNT) had to be employed …

Objective New therapeutic strategies and paradigms are direly needed to treat pancreatic
cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major …

Abstract Fructus Rosae Roxburghii (FRR) has been considered as edible and medicinal fruit
possessing antiatherosclerotic effect, but the mechanism is still unclear. HLP is material …

Recombinant proteins are essential for the treatment and diagnosis of clinical human
ailments. The availability and biological activity of recombinant proteins is heavily influenced …

Pigs have been extensively used as the research models for human disease pathogenesis
and gene therapy. They are also the optimal source of cells, tissues, and organs for …