The degree of airway responsiveness is generally measured by directly activating the airway
smooth muscle (ASM) with incremental doses of inhaled methacholine. In this context …

Is asthma predominately a disease of the large or small airways? The question has vexed
these pages for at least 50 years (1–4) and although a consensus appears to be emerging …

Aim of the study: Force adaptation is a process whereby the contractile capacity of the
airway smooth muscle increases during a sustained contraction (aka tone). Tone also …

Background & Objectives: A sustained contraction of airway smooth muscle, hereinafter
called tone, increases the response to methacholine in healthy mice and humans. However …

Asthma is a serious global health problem affecting 300 million persons around the world.
Mast cells (MCs) play a major role in airway hyperresponsiveness (AHR) and inflammation …

Mathematical modelling has been used in airway and lung physiology with varying degrees
of successes. We review recent progress including patient-specific and multi-scale models …

16 Is asthma predominately a disease of the large or small airways? The question has
vexed 17 these pages for at least 50 years (1-4) and although a consensus appears to be …

Введение. Сужение дыхательных путей вследствие бронхоспазма может приводить к
более выраженным нарушениям регионарной вентиляции и ограничивать газообмен у …

Introduction. The airway constriction due to bronchospasm can lead to more pronounced
disturbances of regional ventilation and limit gas exchange in patients with bronchial …

The hyperconstriction of airway smooth muscle (ASM) is the main driving mechanism during
an asthmatic attack. The airway lumen is reduced, resistance to airflow increases, and …