In this review, we summarize the multiple functions of NQO1, its established roles in redox
processes and potential roles in redox control that are currently emerging. NQO1 has …

NQO1 is one of the two major quinone reductases in mammalian systems. It is highly
inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic …

Oxidative stress causes damage to multiple cellular components such as DNA, proteins, and
lipids, and is implicated in various human diseases including cancer, neurodegeneration …

The presence of a microenvironment within most tumours containing regions of low oxygen
tension or hypoxia has profound biological and therapeutic implications. Tumour hypoxia is …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is
involved in chemoprotection and can also bioactivate certain antitumor quinones. This …

NAD (P) H: quinone oxidoreductase 1 (NQO1) is a key enzyme involved in defence against
reactive forms of oxygen and inhibition of neoplasia. Under conditions of oxidative stress …

Background: Intravesical chemotherapy (ie, placement of the drug directly in the bladder)
with mitomycin C is beneficial for patients with superficial bladder cancer who are at high …

Oxidative stress has been implicated in numerous pathophysiological conditions and also
aging. The tools for studying oxidative stress are now expanding as a result of the human …

Nitro group containing xenobiotics include drugs, cancer chemotherapeutic agents,
carcinogens (eg, nitroarenes and aristolochic acid) and explosives. The nitro group …

Despite the extensive interest in NADPH: quinone oxidoreductase (NQO1, DT-diaphorase),
there is little immunohistochemical information regarding its distribution in either normal …