Deep brain stimulation (DBS) has evolved considerably over the past 4 decades. Although it
has primarily been used to treat movement disorders such as Parkinson's disease, essential …

Chronic pain is a complex neuropsychiatric disorder characterized by sensory, cognitive,
and affective symptoms. Over the past 2 decades, researchers have made significant …

While pharmacological, behavioral and psychosocial treatments are available for substance
use disorders (SUDs), they are not always effective or well-tolerated. Neuromodulation (NM) …

In recent decades, deep brain stimulation (DBS) has been extensively studied due to its
reversibility and significantly fewer side effects. DBS is mainly a symptomatic therapy, but the …

Abstract Treatment resistance in alcohol use disorders (AUD) is a major problem for affected
individuals and for society. In the search of new treatment options, few case studies using …

The comorbidity of depression and addiction has become a serious public health issue, and
the relationship between these two disorders and their potential mechanisms has attracted …

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission
significantly contribute to heroin relapse vulnerability. In animal models, heroin self …

Issues Relapse is a theoretical construct and empirical object of inquiry. It is unclear how
relapse is operationalised with regard to the various phases in substance use disorders …

Objectives Substance use disorder (SUD) is characterized by compulsive use of addictive
substances with considerable impact on both the medical system and society as a whole …

In the face of a global epidemic of drug addiction, neglecting to develop new effective
therapies will perpetuate the staggering human and economic costs of substance use. This …