Simple Summary The biological pathways underlying glioblastoma malignancy and
radioresistance are still unclear. In this review, we describe the role of the hypoxic …

Bridgehead nitrogen (or ring-junction nitrogen) heterocycles are one of the most privileged
scaffolds in synthetic chemistry and medicinal chemistry. For decades, transition metal …

Src plays a crucial role in many signaling pathways and contributes to a variety of cancers.
Therefore, Src has long been considered an attractive drug target in oncology. However, the …

Glioblastoma multiforme (GBM) is one of the most recalcitrant brain tumors characterized by
a tumor microenvironment (TME) that strongly supports GBM growth, aggressiveness …

Proto-oncogene tyrosine-protein kinase Src, also known as c-Src, belongs to the family of
non-receptor tyrosine protein kinases (TKs) called Src kinases. It plays a crucial role in cell …

Overexpression of P-glycoprotein (P-gp) and other ATP-binding cassette (ABC) transporters
in multidrug resistant (MDR) cancer cells is responsible for the reduction of intracellular drug …

Abstract The Bcr-Abl tyrosine kinase (TK) is the molecular hallmark of chronic myeloid
leukemia (CML). Src is another TK kinase whose involvement in CML was widely …

Uncontrolled cell proliferation is a hallmark of cancer as a result of rapid and deregulated
progression through the cell cycle. The inhibition of cyclin-dependent kinases (CDKs) …

Pyrimidine-fused derivatives that are the inextricable part of DNA and RNA play a key role in
the normal life cycle of cells. Pyrimidine-fused dinitrogenous penta-heterocycles, including …

Wee1 kinase plays an important role in regulating G2/M checkpoint and S phase, and the
inhibition of it will lead to mitotic catastrophe in cancer cells with p53 mutation or deletion …