The urothelium is a multifunctional tissue that not only acts as a barrier between the vesical
contents of the lower urinary tract and the underlying tissues but also acts as a sensory …

The epithelial inner layer of the lower urinary tract, ie, the urothelium, and other parts of the
mucosa are not just a passive barrier but play an active role in the sensing of stretching …

OBJECTIVE: To investigate the effects of tissue stretch and muscarinic receptor stimulation
on the spontaneous activity of the urothelium/lamina propria and identify the specific …

Aims RacGTPase-mediated proliferation and smooth muscle contraction in the lower urinary
tract has been recently suggested and may offer putative targets for treamtment of lower …

The urinary bladder has two functions: to store urine, when it is relaxed and highly
compliant; and void its contents, when intravesical pressure rises due to co-ordinated …

ATP is released from the bladder mucosa in response to stretch, but the cell types
responsible are unclear. Our aim was to isolate and characterize individual populations of …

Mirabegron is used for treatment of storage symptoms in overactive bladder (OAB) caused
by spontaneous bladder smooth muscle contractions. However, owing to limitations in …

Introduction Lower urinary tract symptoms (LUTS) due to overactive bladder (OAB) are
caused by spontaneous detrusor contractions. Medical treatment with muscarinic receptor …

The effects of pseudomonal virulence factor pyocyanin, and LPS from Pseudomonas
aeruginosa and Escherichia coli on urothelial mediator release and cytokine production …

Aim This review critically evaluates the evidence on mechanoreceptors and pathways in the
bladder urothelium that are involved in normal bladder filling signalling. Methods Evidence …