Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

Craniofacial deformities (CFDs) develop following oncological resection, trauma, or
congenital disorders. Trauma is one of the top five causes of death globally, with rates …

Bone regeneration following injury is initiated by inflammatory signals and occurs in
association with infiltration by sensory nerve fibers. Together, these events are believed to …

Abstract Purpose of Review Despite advances in orthopedics, there remains a need for
therapeutics to hasten fracture healing. However, little focus is given to the role the nervous …

Abstract Purpose of Review Fractures are a prominent form of traumatic injury and shall
continue to be for the foreseeable future. While the inflammatory response and the cells of …

Abstract Purpose of Review This review examines the diverse functional relationships that
exist between the peripheral nervous system (PNS) and bone, including key advances over …

Although the functions of the peripheral nervous system in whole body homeostasis and
sensation have been understood for many years, recent investigation has uncovered new …

While formation and regeneration of the skeleton have been studied for a long period of
time, significant scientific advances in this field continue to emerge based on an unmet …

Background Exogenous nerve growth factor (NGF) can induce osteogenic precursor cell
differentiation and promote fracture healing. However, the molecular mechanism by which …

Bone morphogenetic protein-2 (BMP-2) has been commercially approved by the Food and
Drug Administration for use in bone defects and diseases. BMP-2 promotes osteogenic …