The role of mucosal barriers in disease progression and transmission
Mucus is a biological hydrogel that coats and protects all non-keratinized wet epithelial
surfaces. Mucins, the primary structural components of mucus, are critical components of the …
surfaces. Mucins, the primary structural components of mucus, are critical components of the …
[HTML][HTML] Aerosol transport modeling: the key link between lung infections of individuals and populations
The recent COVID-19 pandemic has propelled the field of aerosol science to the forefront,
particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic …
particularly the central role of virus-laden respiratory droplets and aerosols. The pandemic …
Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post …
The SARS-CoV-2 coronavirus continues to evolve with scores of mutations of the spike,
membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis …
membrane, envelope, and nucleocapsid structural proteins that impact pathogenesis …
The power of weak, transient interactions across biology: A paradigm of emergent behavior
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …
realizations of a paradigm of emergent behavior. In each of these biological systems …
Elevated ubiquitination contributes to protective immunity against severe SARS‐CoV‐2 infection
Y Che, D Jiang, Y Zhang, J Zhang, T Xu… - Clinical and …, 2022 - Wiley Online Library
Background The crosstalk between the ubiquitin‐proteasome and the immune system plays
an important role in the health and pathogenesis of viral infection. However, there have …
an important role in the health and pathogenesis of viral infection. However, there have …
[HTML][HTML] On a model-based approach to improve intranasal spray targeting for respiratory viral infections
MMH Akash, Y Lao, PA Balivada, P Ato… - Frontiers in Drug …, 2023 - frontiersin.org
The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection
trigger zone along the upper respiratory tract. However, as per the standard recommended …
trigger zone along the upper respiratory tract. However, as per the standard recommended …
[HTML][HTML] Antibody protection from SARS-CoV-2 respiratory tract exposure and infection
The COVID-19 pandemic has underscored the need to understand the dynamics of SARS-
CoV-2 respiratory infection and protection provided by the immune response. SARS-CoV-2 …
CoV-2 respiratory infection and protection provided by the immune response. SARS-CoV-2 …
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response
We develop a lattice-based, hybrid discrete-continuum modeling framework for SARS-CoV-
2 exposure and infection in the human lung alveolar region, or parenchyma, the massive …
2 exposure and infection in the human lung alveolar region, or parenchyma, the massive …
[HTML][HTML] Snoring may transmit infectious aerosols from the upper to the lower respiratory tract
Migration to the lungs of an initial upper airway infection with severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) or other respiratory pathogens can lead to …
syndrome coronavirus 2 (SARS-CoV-2) or other respiratory pathogens can lead to …
[HTML][HTML] Influence of cell type specific infectivity and tissue composition on SARS-CoV-2 infection dynamics within human airway epithelium
B Raach, N Bundgaard, MJ Haase… - PLOS Computational …, 2023 - journals.plos.org
Human airway epithelium (HAE) represents the primary site of viral infection for SARS-CoV-
2. Comprising different cell populations, a lot of research has been aimed at deciphering the …
2. Comprising different cell populations, a lot of research has been aimed at deciphering the …