Physiology and pathophysiology of human airway mucus
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
[HTML][HTML] Physicochemical properties of mucus and their impact on transmucosal drug delivery
Mucus is a selective barrier to particles and molecules, preventing penetration to the
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …
epithelial surface of mucosal tissues. Significant advances in transmucosal drug delivery …
A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia
Mucus clearance is the primary defense mechanism that protects airways from inhaled
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel …
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel …
Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …
Barrier properties of mucus
RA Cone - Advanced drug delivery reviews, 2009 - Elsevier
Mucus is tenacious. It sticks to most particles, preventing their penetration to the epithelial
surface. Multiple low-affinity hydrophobic interactions play a major role in these adhesive …
surface. Multiple low-affinity hydrophobic interactions play a major role in these adhesive …
Nanoparticle diffusion in respiratory mucus from humans without lung disease
A major role of respiratory mucus is to trap inhaled particles, including pathogens and
environmental particulates, to limit body exposure. Despite the tremendous health …
environmental particulates, to limit body exposure. Despite the tremendous health …
Barrier function of airway tract epithelium
S Ganesan, AT Comstock, US Sajjan - Tissue barriers, 2013 - Taylor & Francis
Airway epithelium contributes significantly to the barrier function of airway tract. Mucociliary
escalator, intercellular apical junctional complexes which regulate paracellular permeability …
escalator, intercellular apical junctional complexes which regulate paracellular permeability …
Mucus clearance as a primary innate defense mechanism for mammalian airways
MR Knowles, RC Boucher - The Journal of clinical …, 2002 - Am Soc Clin Investig
Pulmonary defense mechanisms preventing chronic bacterial infection. The lung is depicted
as an inverted funnel, reflecting the relative surface area of distal versus proximal airways …
as an inverted funnel, reflecting the relative surface area of distal versus proximal airways …
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
D Worlitzsch, R Tarran, M Ulrich… - The Journal of …, 2002 - Am Soc Clin Investig
Current theories of CF pathogenesis predict different predisposing “local environmental”
conditions and sites of bacterial infection within CF airways. Here we show that, in CF …
conditions and sites of bacterial infection within CF airways. Here we show that, in CF …
Mucus clearance and lung function in cystic fibrosis with hypertonic saline
SH Donaldson, WD Bennett, KL Zeman… - … England Journal of …, 2006 - Mass Medical Soc
Background Abnormal homeostasis of the volume of airway surface liquid in patients with
cystic fibrosis is thought to produce defects in mucus clearance and airway defense …
cystic fibrosis is thought to produce defects in mucus clearance and airway defense …