Acetylcholinesterase inhibitors from plants and fungi

PJ Houghton, Y Ren, MJ Howes - Natural product reports, 2006 - pubs.rsc.org
Covering: January 1980 to August 2005This review describes 183 compounds obtained
from plants and fungi which have been shown to inhibit acetylcholinesterase. The …

Simple indole alkaloids and those with a nonrearranged monoterpenoid unit

T Kawasaki, K Higuchi - Natural product reports, 2005 - pubs.rsc.org
Simple indole alkaloids and those with a nonrearranged monoterpenoid unit - Natural Product
Reports (RSC Publishing) DOI:10.1039/B502162F Royal Society of Chemistry View PDF …

β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy

A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

The influence of alkaloids on oxidative stress and related signaling pathways

K Macáková, R Afonso, L Saso, P Mladěnka - Free Radical Biology and …, 2019 - Elsevier
Alkaloids have always attracted scientific interest due to either their positive or negative
effects on human beings. This review aims to summarize their antioxidant effects by both …

Natural products inhibitors of the enzyme acetylcholinesterase

JM Barbosa Filho, KCP Medeiros… - Revista Brasileira de …, 2006 - SciELO Brasil
Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily
affects the elderly population, and is estimated to account for 50-60% of dementia cases in …

Metabolite Diversity in Alkaloid Biosynthesis: A Multilane (Diastereomer) Highway for Camptothecin Synthesis in Camptotheca acuminata

R Sadre, M Magallanes-Lundback, S Pradhan… - The Plant …, 2016 - academic.oup.com
Camptothecin is a monoterpene indole alkaloid (MIA) used to produce semisynthetic
antitumor drugs. We investigated camptothecin synthesis in Camptotheca acuminata by …

Natural product inhibitors of acetylcholinesterase

K Hostettmann, A Borloz, A Urbain… - Current Organic …, 2006 - ingentaconnect.com
Various natural products, such as physostigmine, have long been recognized as inhibitors of
the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the …

Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme

MT Andrade, JA Lima, AC Pinto, CM Rezende… - Bioorganic & medicinal …, 2005 - Elsevier
Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis
(Müell. Arg) Miers were tentatively identified by GC–MS, viz., coronaridine (1), voacangine …

Traditional uses, phytochemistry and pharmacological properties of African Nauclea species: A review

R Haudecoeur, M Peuchmaur, B Pérès, M Rome… - Journal of …, 2018 - Elsevier
Abstract Ethnopharmacoalogical relevance The genus Nauclea in Africa comprises seven
species. Among them, N. latifolia, N. diderrichii and N. pobeguinii are widely used by the …

In silico modeling for dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes in Alzheimer's disease

V Kumar, A Saha, K Roy - Computational Biology and Chemistry, 2020 - Elsevier
In this research, we have implemented two-dimensional quantitative structure-activity
relationship (2D-QSAR) modeling using two different datasets, namely, acetylcholinesterase …