MicroRNAs, identified in the early 1990s, are believed to regulate approximately 30% of the
human genome. The role of microRNA in bone cells was first reported in 2007 in a …

Although the recent recognition of osteosarcopenia as a single diagnosis of bone and
muscle deterioration has provided new insights into the mechanisms of these underlying …

Context Measurement of circulating microRNAs (miRNAs) as potential biomarkers of fragility
fracture risk has recently become a subject of investigation. Objective Measure by next …

Vertebrate sexual dimorphism is ascribed to the presence of testes or ovaries, and, hence, to
the secretion of gonad-specific hormones. However, mounting evidence indicates that sex …

Abstract Background Osteocytic microRNA21 (miR21) removal alters cytokine production
and bone mass by modulating osteoclast and osteoblast differentiation and activity …

Previous studies proposed the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2),
a receptor expressed in myeloid cells including microglia in brain and osteoclasts in bone …

Abstract Purpose of Review The present review will highlight recent reports supporting the
relevance of extracellular vesicles to the musculoskeletal system in health and disease …

Low levels of microRNA (miR) 21 may explain the higher osteocyte apoptosis with Cx43-
deficient and aged female mice. However, miR21 exerts a sex-divergent role in osteocytes …

Abstract Pannexin1 (Panx1) is a hemichannel-forming protein that participates in the
communication of cells with the extracellular space. To characterize the role of osteoclastic …

Simple Summary Osteoporosis is a disease that is characterized by bone mass loss and
microarchitecture deterioration, due to alterations in the bone remodeling mechanism, which …