Purpose of Review WEE1 inhibitor has been shown to potential chemotherapy or
radiotherapy sensitivity in preclinical models, particularly in p53-mutated or deficient cancer …

Background Traditionally, within dose-finding clinical trials, treatment toxicity and tolerability
are assessed by clinicians. Research has shown that clinician reporting may have …

Oral cancer has been a major problem all across the globe, majorly in the developing
countries. With a growing emphasis in the field of cancer research, the contribution of the …

Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

Cells experience both endogenous and exogenous DNA damage daily. To maintain
genome integrity and suppress tumorigenesis, individuals have evolutionarily acquired a …

In head and neck squamous cell carcinoma (HNSCC), tumors positive for human
papillomavirus (HPV) represent a distinct biological entity with favorable prognosis. An …

Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …

Introduction For advanced hepatocellular carcinoma (HCC), resistance to conservative
treatments remains a challenge. In previous studies, the therapeutic effectiveness and DNA …

Data regarding driver mutation profiles in tonsillar squamous cell carcinomas (TSCCs)
remain scarce, limiting the understanding of its pathogenesis and unexpected behavior in …

Objective Oral tongue squamous cell carcinoma (OTSCC) frequently harbors non‐functional
p53 and depends on G2/M checkpoint mediated by WEE1. WEE1 suppression has been …