An interoceptive homeostatic system monitors levels of CO2/H+ and provides a
proportionate drive to respiratory control networks that adjust lung ventilation to maintain …

Breathing is regulated by a host of arousal and sleep-wake state-dependent
neuromodulators to maintain respiratory homeostasis. Modulators such as acetylcholine …

Central chemoreception is essential for adjusting breathing to physiological demands, and
for maintaining CO2 and pH homeostasis in the brain. CO2-induced ATP release from …

Respiratory chemoreceptors regulate breathing in response to changes in tissue CO2/H+.
Blood flow is a fundamental determinant of tissue CO2/H+, yet little is known regarding how …

Cerebral blood flow is highly sensitive to changes in CO2/H+ where an increase in CO2/H+
causes vasodilation and increased blood flow. Tissue CO2/H+ also functions as the main …

Orofacial inflammation leads to transcriptional alterations in trigeminal ganglion (TG)
neurons. However, diverse alterations and regulatory mechanisms following orofacial …

The nucleus tractus solitarii (NTS) is implicated in the control of breathing, but the neuronal
phenotype and circuit mechanism involved in such a physiological function remain …

New Findings What is the central question of this study? What is the relationship between
neuroanatomical and functional respiratory changes in an experimental model of …

Inflammation-induced release of prostaglandin E2 (PGE2) changes breathing patterns and
the response to CO2 levels. This may have fatal consequences in newborn babies and …

Mayer waves may synchronize overlapping propriobulbar interneuronal microcircuits
constituting the respiratory rhythm and pattern generator, sympathetic oscillators, and …