Abstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer,
and such hyperactivation is generally associated with a poor clinical prognosis. In the …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Disease overview The eosinophilias encompass a broad range of non‐hematologic
(secondary or reactive) and hematologic (primary or clonal) disorders with potential for end …

Recently the World Health Organization (WHO), in collaboration with the European
Association for Haematopathology and the Society for Hematopathology, published a …

Background The molecular causes of many hematologic cancers remain unclear. Among
these cancers are chronic neutrophilic leukemia (CNL) and atypical (BCR-ABL1–negative) …

Disease overview The eosinophilias encompass a broad range of nonhematologic
(secondary or reactive) and hematologic (primary, clonal) disorders with potential for end …

Background The JAK2V617F allele has recently been identified in patients with
polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid …

Background The V617F mutation, which causes the substitution of phenylalanine for valine
at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with …

Abstract The 2001 World Health Organization (WHO) treatise on the classification of
hematopoietic tumors lists chronic myeloproliferative diseases (CMPDs) as a subdivision of …