[HTML][HTML] Inflammation and aging: signaling pathways and intervention therapies
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …
[HTML][HTML] Blood-to-brain communication in aging and rejuvenation
Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
cognitive decline and increase vulnerability to dementia-related neurodegenerative …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
The decisive early phase of bone regeneration
Bone has a remarkable endogenous regenerative capacity that enables scarless healing
and restoration of its prior mechanical function, even under challenging conditions such as …
and restoration of its prior mechanical function, even under challenging conditions such as …
Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
Genetic engineering meets hematopoietic stem cell biology for next-generation gene therapy
The growing clinical success of hematopoietic stem/progenitor cell (HSPC) gene therapy
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
(GT) relies on the development of viral vectors as portable" Trojan horses" for safe and …
[PDF][PDF] Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Aged hematopoietic stem cells (HSCs) display diminished self-renewal and a myeloid
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …
differentiation bias. However, the drivers and mechanisms that underpin this fundamental …
[HTML][HTML] Cholesterol confers ferroptosis resistance onto myeloid-biased hematopoietic stem cells and prevents irradiation-induced myelosuppression
C Liu, W Liao, J Chen, K Yu, Y Wu, S Zhang, M Chen… - Redox Biology, 2023 - Elsevier
There is growing appreciation that hematopoietic alterations underpin the ubiquitous
detrimental effects of metabolic disorders. The susceptibility of bone marrow (BM) …
detrimental effects of metabolic disorders. The susceptibility of bone marrow (BM) …
The genetic determinants of recurrent somatic mutations in 43,693 blood genomes
JS Weinstock, CA Laurie, JG Broome, KD Taylor… - Science …, 2023 - science.org
Nononcogenic somatic mutations are thought to be uncommon and inconsequential. To test
this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision …
this, we analyzed 43,693 National Heart, Lung and Blood Institute Trans-Omics for Precision …
[HTML][HTML] Spotlight on the impact of viral infections on Hematopoietic Stem Cells (HSCs) with a focus on COVID-19 effects
K Nasiri, S Mohammadzadehsaliani… - Cell Communication and …, 2023 - Springer
Hematopoietic stem cells (HSCs) are known for their significant capability to reconstitute and
preserve a functional hematopoietic system in long-term periods after transplantation into …
preserve a functional hematopoietic system in long-term periods after transplantation into …