Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Local and cross-border importation remain major challenges to malaria elimination and are
difficult to measure using traditional surveillance data. To address this challenge, we …

Malaria genomic surveillance often estimates parasite genetic relatedness using metrics
such as Identity-By-Decent (IBD), yet strong positive selection stemming from antimalarial …

Zanzibar has made significant progress toward malaria elimination, but recent stagnation
requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR) …

For countries aiming for malaria elimination, travel of infected individuals between endemic
areas undermines local interventions. Quantifying parasite importation has therefore …

Next-generation sequencing (NGS) technologies are increasingly being used to address a
diverse range of biological and epidemiological questions. The current understanding of …

As data at progressively granular spatial scales become available, the temptation is to target
interventions to areas with higher malaria transmission–so-called hotspots–with the aim of …

Background Targeted next-generation sequencing offers the potential for consistent, deep
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …

Background While traditional epidemiological approaches have supported significant
reductions in malaria incidence across many countries, higher resolution information about …