Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Creutzfeldt–Jakob disease and other prion diseases
Prion diseases share common clinical and pathological characteristics such as spongiform
neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed …
neuronal degeneration and deposition of an abnormal form of a host-derived protein, termed …
MoDAFold: a strategy for predicting the structure of missense mutant protein based on AlphaFold2 and molecular dynamics
Protein structure prediction is a longstanding issue crucial for identifying new drug targets
and providing a mechanistic understanding of protein functions. To enhance the progress in …
and providing a mechanistic understanding of protein functions. To enhance the progress in …
Cryo-EM of prion strains from the same genotype of host identifies conformational determinants
Prion strains in a given type of mammalian host are distinguished by differences in clinical
presentation, neuropathological lesions, survival time, and characteristics of the infecting …
presentation, neuropathological lesions, survival time, and characteristics of the infecting …
Prion strains viewed through the lens of cryo-EM
SW Manka, A Wenborn, J Collinge… - Cell and Tissue …, 2023 - Springer
Mammalian prions are lethal transmissible pathogens that cause fatal neurodegenerative
diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion …
diseases in humans and animals. They consist of fibrils of misfolded, host-encoded prion …
Cryo-EM structures of cotton wool plaques' amyloid β and of tau filaments in dominantly inherited Alzheimer disease
Cotton wool plaques (CWPs) have been described as features of the neuropathologic
phenotype of dominantly inherited Alzheimer disease (DIAD) caused by some missense and …
phenotype of dominantly inherited Alzheimer disease (DIAD) caused by some missense and …
Emerging trends in cryo-EM-based structural studies of neuropathological amyloids
S Mishra - Journal of Molecular Biology, 2023 - Elsevier
Tauopathies, synucleinopathies, Aβ amyloidosis, TDP-43 proteinopathies, and prion
diseases-these neurodegenerative diseases have in common the formation of amyloid …
diseases-these neurodegenerative diseases have in common the formation of amyloid …
[HTML][HTML] The structural line between prion and “prion-like”: Insights from prion protein and tau
The concept of 'prion-like'behavior has emerged in the study of diseases involving protein
misfolding where fibrillar structures, called amyloids, self-propagate and induce disease in a …
misfolding where fibrillar structures, called amyloids, self-propagate and induce disease in a …
Cross-β helical filaments of tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia
In neurodegenerative diseases and aging, the microtubuleassociated protein tau (MAPT)
and the transmembrane lysosomal protein 106B (TMEM106B) become misfolded in different …
and the transmembrane lysosomal protein 106B (TMEM106B) become misfolded in different …
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis
ATTR amyloidosis results from the conversion of transthyretin into amyloid fibrils that deposit
in tissues causing organ failure and death. This conversion is facilitated by mutations in …
in tissues causing organ failure and death. This conversion is facilitated by mutations in …