Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

The cohesin complex has an essential role in maintaining genome organization. However,
its role in gene regulation remains largely unresolved. Here we report that the cohesin …

Cohesin and CTCF are major drivers of 3D genome organization, but their role in neurons is
still emerging. Here, we show a prominent role for cohesin in the expression of genes that …

Cohesin is important for 3D genome organization. Nevertheless, even the complete removal
of cohesin has surprisingly little impact on steady-state gene transcription and enhancer …

In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

Mutations of the cohesin complex in human cancer were first discovered~ 10 years ago.
Since then, researchers worldwide have demonstrated that cohesin is among the most …

Innate immune responses rely on inducible gene expression programmes which, in contrast
to steady-state transcription, are highly dependent on cohesin. Here we address …

The cohesin complex has a range of crucial functions in the cell. Cohesin is essential for
mediating chromatid cohesion during mitosis, for repair of double‐strand DNA breaks, and …