The role of purinergic P2X7 receptor in inflammation and cancer: novel molecular insights and clinical applications

JC Rotondo, C Mazziotta, C Lanzillotti, C Stefani… - Cancers, 2022 - mdpi.com
Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …

Purinergic modulation of the immune response to infections

N Eberhardt, G Bergero, YL Mazzocco Mariotta… - Purinergic …, 2022 - Springer
Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi,
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …

High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity

GB da Silva, D Manica, AP da Silva… - Journal of Molecular …, 2022 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
significantly impacted the world and has driven many researchers into the pathophysiology …

Role of CD39 in COVID-19 severity: dysregulation of purinergic signaling and thromboinflammation

E Díaz-García, S García-Tovar, E Alfaro… - Frontiers in …, 2022 - frontiersin.org
CD39/NTPDase1 has emerged as an important molecule that contributes to maintain
inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible …

Pannexin-1 channel opening is critical for COVID-19 pathogenesis

R Luu, S Valdebenito, E Scemes, A Cibelli, DC Spray… - Iscience, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged
worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS …

Sepsis-induced acute lung injury is alleviated by small molecules from dietary plants via pyroptosis modulation

J Wu, Y Lan, J Wu, K Zhu - Journal of Agricultural and Food …, 2023 - ACS Publications
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality, and it has three major pathogeneses, namely alveolar–capillary barrier …

[HTML][HTML] Receptors involved in COVID-19-related anosmia: An update on the pathophysiology and the mechanistic aspects

NN Al-Saigh, AA Harb, S Abdalla - International Journal of Molecular …, 2024 - mdpi.com
Olfactory perception is an important physiological function for human well-being and health.
Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory …

CD73: friend or foe in lung injury

XM Hu, NR Shi, JZ Zhang, YQ Zuo, X Wang… - International Journal of …, 2023 - mdpi.com
Ecto-5′-nucleotidase (CD73) plays a strategic role in calibrating the magnitude and
chemical nature of purinergic signals that are delivered to immune cells. Its primary function …

Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients

IC Schultz, APS Bertoni, MR Wink - Journal of Molecular Medicine, 2022 - Springer
For over a year, the coronavirus disease 2019 has been affecting the world population by
causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) …

The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity

X Cai, Y Yao, F Teng, Y Li, L Wu, W Yan… - International …, 2021 - Elsevier
Abstract The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor
family. It is distributed in various tissues of the human body and is involved in regulating the …