The role of purinergic P2X7 receptor in inflammation and cancer: novel molecular insights and clinical applications
JC Rotondo, C Mazziotta, C Lanzillotti, C Stefani… - Cancers, 2022 - mdpi.com
Simple Summary The purinergic P2X7 receptor (P2X7R) is a cell membrane protein whose
activation has been related to a variety of cellular processes, while its dysregulation has …
activation has been related to a variety of cellular processes, while its dysregulation has …
Purinergic modulation of the immune response to infections
N Eberhardt, G Bergero, YL Mazzocco Mariotta… - Purinergic …, 2022 - Springer
Infectious diseases are caused by the invasion of pathogenic microorganisms such as fungi,
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …
bacteria, viruses, and parasites. After infection, disease progression relies on the complex …
High levels of extracellular ATP lead to different inflammatory responses in COVID-19 patients according to the severity
GB da Silva, D Manica, AP da Silva… - Journal of Molecular …, 2022 - Springer
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
significantly impacted the world and has driven many researchers into the pathophysiology …
significantly impacted the world and has driven many researchers into the pathophysiology …
Role of CD39 in COVID-19 severity: dysregulation of purinergic signaling and thromboinflammation
E Díaz-García, S García-Tovar, E Alfaro… - Frontiers in …, 2022 - frontiersin.org
CD39/NTPDase1 has emerged as an important molecule that contributes to maintain
inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible …
inflammatory and coagulatory homeostasis. Various studies have hypothesized the possible …
Pannexin-1 channel opening is critical for COVID-19 pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapidly rampaged
worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS …
worldwide, causing a pandemic of coronavirus disease (COVID-19), but the biology of SARS …
Sepsis-induced acute lung injury is alleviated by small molecules from dietary plants via pyroptosis modulation
J Wu, Y Lan, J Wu, K Zhu - Journal of Agricultural and Food …, 2023 - ACS Publications
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality, and it has three major pathogeneses, namely alveolar–capillary barrier …
mortality, and it has three major pathogeneses, namely alveolar–capillary barrier …
[HTML][HTML] Receptors involved in COVID-19-related anosmia: An update on the pathophysiology and the mechanistic aspects
Olfactory perception is an important physiological function for human well-being and health.
Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory …
Loss of olfaction, or anosmia, caused by viral infections such as severe acute respiratory …
CD73: friend or foe in lung injury
XM Hu, NR Shi, JZ Zhang, YQ Zuo, X Wang… - International Journal of …, 2023 - mdpi.com
Ecto-5′-nucleotidase (CD73) plays a strategic role in calibrating the magnitude and
chemical nature of purinergic signals that are delivered to immune cells. Its primary function …
chemical nature of purinergic signals that are delivered to immune cells. Its primary function …
Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients
IC Schultz, APS Bertoni, MR Wink - Journal of Molecular Medicine, 2022 - Springer
For over a year, the coronavirus disease 2019 has been affecting the world population by
causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) …
causing severe tissue injuries and death in infected people. Adenosine triphosphate (ATP) …
The role of P2X7 receptor in infection and metabolism: Based on inflammation and immunity
X Cai, Y Yao, F Teng, Y Li, L Wu, W Yan… - International …, 2021 - Elsevier
Abstract The P2X7 receptor (P2X7R) is a ligand-gated receptor belonging to the P2 receptor
family. It is distributed in various tissues of the human body and is involved in regulating the …
family. It is distributed in various tissues of the human body and is involved in regulating the …