Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents
In this review we will explore recent advances in the design and application of excited-state
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …
[HTML][HTML] Drug-induced liver injury
D Katarey, S Verma - Clinical Medicine, 2016 - Elsevier
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF)
in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the …
in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the …
Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
BACKGROUND & AIMS: Idiosyncratic drug-induced liver injury (DILI) is among the most
common causes of acute liver failure in the United States, accounting for approximately 13 …
common causes of acute liver failure in the United States, accounting for approximately 13 …
Mechanisms of drug-induced liver injury
L Yuan, N Kaplowitz - Clinics in liver disease, 2013 - liver.theclinics.com
Drug-induced liver injury (DILI) occurs in an incidence of 10 to 15 in 10, 000 to 100,000 in
the United States, 1, 2 yet it has caused remarkable fatalities from acute liver failure yearly …
the United States, 1, 2 yet it has caused remarkable fatalities from acute liver failure yearly …
Oxidative stress, genomic integrity, and liver diseases
N Sadasivam, YJ Kim, K Radhakrishnan, DK Kim - Molecules, 2022 - mdpi.com
Excess reactive oxygen species production and free radical formation can lead to oxidative
stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the …
stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the …
Molecular mechanisms underlying chemical liver injury
X Gu, JE Manautou - Expert reviews in molecular medicine, 2012 - cambridge.org
The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
the metabolism of xenobiotics render this organ particularly susceptible to injury by …
Drug-induced liver injury
MD Leise, JJ Poterucha, JA Talwalkar - Mayo clinic proceedings, 2014 - Elsevier
Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or
idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug …
idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug …
[PDF][PDF] The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug‐induced liver injury
A Suzuki, EM Brunt, DE Kleiner, R Miquel… - …, 2011 - Wiley Online Library
Distinguishing drug‐induced liver injury (DILI) from idiopathic autoimmune hepatitis (AIH)
can be challenging. We performed a standardized histologic evaluation to explore potential …
can be challenging. We performed a standardized histologic evaluation to explore potential …
Drug‐induced liver injury: clinical evidence of N‐acetyl cysteine protective effects
Y Ntamo, K Ziqubu, N Chellan… - Oxidative medicine …, 2021 - Wiley Online Library
Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans
S Dawson, S Stahl, N Paul, J Barber… - Drug Metabolism and …, 2012 - ASPET
Inhibition of the activity of the human bile salt export pump (BSEP: ABCB11) has been
proposed to play a role in drug-induced liver injury (DILI). To enhance understanding of the …
proposed to play a role in drug-induced liver injury (DILI). To enhance understanding of the …