In this review we will explore recent advances in the design and application of excited-state
intramolecular proton-transfer (ESIPT) based fluorescent probes. Fluorescence based …

Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF)
in the western world. Excluding paracetamol overdose, nearly all DILI encountered in the …

BACKGROUND & AIMS: Idiosyncratic drug-induced liver injury (DILI) is among the most
common causes of acute liver failure in the United States, accounting for approximately 13 …

Drug-induced liver injury (DILI) occurs in an incidence of 10 to 15 in 10, 000 to 100,000 in
the United States, 1, 2 yet it has caused remarkable fatalities from acute liver failure yearly …

Excess reactive oxygen species production and free radical formation can lead to oxidative
stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the …

The liver is necessary for survival. Its strategic localisation, blood flow and prominent role in
the metabolism of xenobiotics render this organ particularly susceptible to injury by …

Drug hepatoxicity can be nonidiosyncratic (predictable), as in the case of acetaminophen, or
idiosyncratic (unpredictable). This review article focuses primarily on idiosyncratic drug …

Distinguishing drug‐induced liver injury (DILI) from idiopathic autoimmune hepatitis (AIH)
can be challenging. We performed a standardized histologic evaluation to explore potential …

Oxidative stress is a key pathological feature implicated in both acute and chronic liver
diseases, including drug‐induced liver injury (DILI). The latter describes hepatic injury …

Inhibition of the activity of the human bile salt export pump (BSEP: ABCB11) has been
proposed to play a role in drug-induced liver injury (DILI). To enhance understanding of the …