Small nucleolar RNAs (snoRNAs) are a large class of small noncoding RNAs present in all
eukaryotes sequenced thus far. As a family, they have been well characterized as playing a …

The ribosome, central to protein synthesis in all cells, is a complex multicomponent
assembly with rRNA at its functional core. During the process of ribosome biogenesis …

Box C/D and box H/ACA snoRNAs are abundant non-coding RNAs that localize in the
nucleolus and mostly function as guides for nucleotide modifications. While a large pool of …

A myriad of structurally and functionally diverse noncoding RNAs (ncRNAs) have recently
been implicated in numerous human diseases including cancer. Small nucleolar RNAs …

Deletion of 3p13 has been reported from about 20% of prostate cancers. The clinical
significance of this alteration and the tumour suppressor gene (s) driving the deletion remain …

Hoyeraal–Hreidarsson (HH) syndrome is a multisystem genetic disorder characterized by
very short telomeres and considered a clinically severe variant of dyskeratosis congenita …

Abstract The R2TP/Prefoldin-like (R2TP/PFDL) complex has emerged as a cochaperone
complex involved in the assembly of a number of critical protein complexes including …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Box H/ACA ribonucleoproteins (RNPs), each consisting of one unique guide RNA and 4
common core proteins, constitute a family of complex enzymes that catalyze, in an RNA …

The vast body of literature regarding human telomere maintenance is a true testament to the
importance of understanding telomere regulation in both normal and diseased states. In this …