Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Mitochondria are one of the major ancient endomembrane systems in eukaryotic cells.
Owing to their ability to produce ATP through respiration, they became a driving force in …

The spatial regulation of protein translation is an efficient way to create functional and
structural asymmetries in cells. Recent research has furthered our understanding of how …

T cells maintain a quiescent state prior to activation. As inappropriate T cell activation can
cause disease, T cell quiescence must be preserved. Despite its importance, the …

Multiple deadenylases are known in vertebrates, the PAN2-PAN3 (PAN2/3) and CCR4-NOT
(CNOT) complexes, and PARN, yet their differential functions remain ambiguous. Moreover …

Most mitochondrial proteins are encoded in the nucleus. They are synthesized as precursor
forms in the cytosol and must be imported into mitochondria with the help of different protein …

We employed electron cryo‐tomography to visualize cytosolic ribosomes on the surface of
mitochondria. Translation‐arrested ribosomes reveal the clustered organization of the TOM …

RNA localization mechanisms have been intensively studied and include localized
protection of mRNA from degradation, diffusion-coupled local entrapment of mRNA, and …

Eukaryotes organize cellular contents into membrane-bound organelles and membrane-
less condensates, for example, protein aggregates. An unsolved question is why the …

While targeting of proteins synthesized in the cytosol to any organelle is complex,
mitochondria present the most challenging of destinations. First, import of nuclear-encoded …