Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms
A Saha, D Bello, A Fernández-Tejada - Chemical Society Reviews, 2021 - pubs.rsc.org
The addition of O-linked-β-DN-acetylglucosamine (O-GlcNAc) onto serine and threonine
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …
residues of nuclear and cytoplasmic proteins is an abundant, unique post-translational …
O-linked β-N-acetylglucosamine (O-GlcNAc): extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress
C Butkinaree, K Park, GW Hart - … et Biophysica Acta (BBA)-General Subjects, 2010 - Elsevier
BACKGROUND: Since its discovery in the early 1980s, O-linked-β-N-acetylglucosamine (O-
GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues …
GlcNAc), a single sugar modification on the hydroxyl group of serine or threonine residues …
The human O-GlcNAcome database and meta-analysis
E Wulff-Fuentes, RR Berendt, L Massman, L Danner… - Scientific data, 2021 - nature.com
Abstract Over the past 35 years,~ 1700 articles have characterized protein O-GlcNAcylation.
Found in almost all living organisms, this post-translational modification of serine and …
Found in almost all living organisms, this post-translational modification of serine and …
Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress: a survival response of mammalian cells
NE Zachara, N O'Donnell, WD Cheung… - Journal of Biological …, 2004 - ASBMB
Cellular response to environmental, physiological, or chemical stress is key to survival
following injury or disease. Here we describe a unique signaling mechanism by which cells …
following injury or disease. Here we describe a unique signaling mechanism by which cells …
Finding the weakest link–exploring integrin-mediated mechanical molecular pathways
P Roca-Cusachs, T Iskratsch… - Journal of cell …, 2012 - journals.biologists.com
From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …
to their environment. Molecules in this network transmit and detect mechanical forces, which …
The hexosamine signaling pathway: deciphering the" O-GlcNAc code"
DC Love, JA Hanover - Science's STKE, 2005 - science.org
A dynamic cycle of addition and removal of O-linked N-acetylglucosamine (O-GlcNAc) at
serine and threonine residues is emerging as a key regulator of nuclear and cytoplasmic …
serine and threonine residues is emerging as a key regulator of nuclear and cytoplasmic …
O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress
NE Zachara, GW Hart - Biochimica et Biophysica Acta (BBA)-General …, 2004 - Elsevier
Myriad nuclear and cytoplasmic proteins in metazoans are modified on Ser and Thr residues
by the monosaccharide O-linked β-N-acetylglucosamine (O-GlcNAc). The rapid and …
by the monosaccharide O-linked β-N-acetylglucosamine (O-GlcNAc). The rapid and …
Cell signaling, the essential role of O-GlcNAc!
NE Zachara, GW Hart - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2006 - Elsevier
An increasing body of evidence points to a central regulatory role for glucose in mediating
cellular processes and expands the role of glucose well beyond its traditional role (s) in …
cellular processes and expands the role of glucose well beyond its traditional role (s) in …
Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity
The abundant and dynamic post-translational modification of nuclear and cytosolic proteins
by β-O-linked N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc-transferase (OGT) …
by β-O-linked N-acetylglucosamine (O-GlcNAc) is catalyzed by O-GlcNAc-transferase (OGT) …
Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins—a role in nuclear localization
T Lefebvre, S Ferreira, L Dupont-Wallois… - … et Biophysica Acta (BBA …, 2003 - Elsevier
Both phosphorylation and O-GlcNAc glycosylation posttranslationally modify microtubule-
associated Tau proteins. Whereas the hyperphosphorylation of these proteins that occurs in …
associated Tau proteins. Whereas the hyperphosphorylation of these proteins that occurs in …