Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …
treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a …
Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma
H Lv, X Liu, X Zeng, Y Liu, C Zhang… - Frontiers in …, 2022 - frontiersin.org
Skin cutaneous melanoma (SKCM, hereafter referred to as melanoma) is the most lethal
skin cancer with increasing incidence. Regulated cell death plays an important role in …
skin cancer with increasing incidence. Regulated cell death plays an important role in …
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
L Codarri Deak, V Nicolini, M Hashimoto, M Karagianni… - Nature, 2022 - nature.com
Expansion and differentiation of antigen-experienced PD-1+ TCF-1+ stem-like CD8+ T cells
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
[HTML][HTML] The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
T regulatory (Treg) cells are crucial to maintain immune tolerance and repress antitumor
immunity, but the mechanisms governing their cellular redox homeostasis remain elusive …
immunity, but the mechanisms governing their cellular redox homeostasis remain elusive …
Comprehensive review of targeted therapy for colorectal cancer
YH Xie, YX Chen, JY Fang - Signal transduction and targeted therapy, 2020 - nature.com
Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …
Intricacies of TGF-β signaling in Treg and Th17 cell biology
Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …
central to the balance between immune tolerance and immune rejection. Th cells adopt …
Nanoparticle‐enhanced radiotherapy to trigger robust cancer immunotherapy
External radiotherapy is extensively used in clinic to destruct tumors by locally applied
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
Self-assembled peptide and protein nanostructures for anti-cancer therapy: Targeted delivery, stimuli-responsive devices and immunotherapy
Self-assembled peptides and proteins possess tremendous potential as targeted drug
delivery systems and key applications of these well-defined nanostructures reside in anti …
delivery systems and key applications of these well-defined nanostructures reside in anti …
[HTML][HTML] FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets
T Regulatory cells (Tregs) can have both protective and pathological roles. They maintain
immune homeostasis and inhibit immune responses in various diseases, including cancer …
immune homeostasis and inhibit immune responses in various diseases, including cancer …