A critical review on granulation of pharmaceuticals and excipients: Principle, analysis and typical applications

B Wang, X Sun, J Xiang, X Guo, Z Cheng, W Liu… - Powder Technology, 2022 - Elsevier
Solid dosage forms require the addition of different types of excipients such as flowability,
compressibility, disintegration, solubility, stability and other physical and chemical properties …

PBM of an industrial-scale vertical wet stirred media mill (HIGMill): Assessment of back-calculation and hybrid methods

E Bilgili, A Toprak, D Altun, O Altun - Powder Technology, 2024 - Elsevier
An industrial-scale vertical wet stirred media mill (HIGMill) was simulated via a population
balance model (PBM). Feed and product particle size distributions (PSDs) of copper ore …

A Novel PBM for Nanomilling of Drugs in a Recirculating Wet Stirred Media Mill: Impacts of Batch Size, Flow Rate, and Back-Mixing

H Heidari, N Muanpaopong, G Guner, HF Yao… - Pharmaceutics, 2024 - mdpi.com
We examined the evolution of fenofibrate (FNB, drug) particle size distribution (PSD) during
the production of nanosuspensions via wet stirred media milling (WSMM) with a cell-based …

Population balance modelling of ribbon milling with a new mass-based breakage function

B Olaleye, F Pozza, CY Wu, LX Liu - International Journal of Pharmaceutics, 2019 - Elsevier
Dry granulation through roll compaction followed by milling is a widely used pharmaceutical
process. The material properties of powders and the roll compaction process conditions …

Simulation of gas-solid adsorption process considering particle-size distribution

J Li, B Zhang, Y Shu - Chinese Journal of Chemical Engineering, 2023 - Elsevier
The particle-size distribution of adsorbents usually plays an important role on the adsorption
performance. In this study, population balance equation (PBE) is utilized in the simulation of …

Integration of Lineal Geostatistical Analysis and Computational Intelligence to Evaluate the Batch Grinding Kinetics

FA Lucay, J Delgado, FD Sepúlveda - Minerals, 2022 - mdpi.com
The kinetic characterization of the grinding process has always faced a special challenge
due to the constant fluctuations of its parameters. The weight percentage of each size …

Experimental uncertainty analysis for the particle size distribution for better understanding of batch grinding process

J Delgado, FA Lucay, FD Sepúlveda - Minerals, 2021 - mdpi.com
Uncertainty in industrial processes is very common, but it is particularly high in the grinding
process (GP), due to the set of interacting operating/design parameters. This uncertainty can …

Математическое моделирование процесса измельчения материалов

ЭМ Кольцова, ЭМ Кольцова… - Teoretičeskie …, 2024 - journals.rcsi.science
На основе знания термодинамических потоков и движущих сил процесса дробления и
применения принципа минимума производства энтропии получена зависимость для …

Simulation of activated carbon adsorption process considering particle size distribution.

LI Jihui, SHU Yidan - Acta Scientiarum Naturalium …, 2022 - search.ebscohost.com
In this paper, we establish an adsorption process model considering particle size distribution
based on the population balance model to analyze the effects of particle size distribution of …

[PDF][PDF] Data-Driven Insight into Ball Mill Scaling

UDA Scales, B Doroszuk, B Eng - researchgate.net
Although ball mills are important elements in the mineral processing industry, optimizing and
scaling up their performance remains a challenge. This thesis aims to gain insights into ball …