In addition to ghrelin's effects on appetite and adiposity, ghrelin signalling also plays crucial
roles in glucose and energy homeostasis, cardioprotection, muscle atrophy and bone …

Congenital hyperinsulinism (CHI) is a heterogenous and complex disorder in which the
unregulated insulin secretion from pancreatic beta-cells leads to hyperinsulinaemic …

Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Hyperinsulinemic hypoglycemia (HH) is characterized by unregulated insulin release,
leading to persistently low blood glucose concentrations with lack of alternative fuels, which …

Congenital hypopituitarism (CH) is characterized by the deficiency of one or more pituitary
hormones and can present alone or in association with complex disorders. Congenital …

Hyperinsulinaemic hypoglycaemia (HH) is a heterogeneous condition with dysregulated
insulin secretion which persists in the presence of low blood glucose levels. It is the most …

In HH there is dysregulation of insulin secretion so that insulin continues to be secreted
despite blood glucose levels being in the hypoglycemic range. Typically HH occurs in the …

Purpose Molecular basis of various forms of hyperinsulinemic hypoglycemia, involving
defects in key genes regulating insulin secretion, are being increasingly reported. However …

Glucose is an essential substrate for mammalian cells; in particular, the brain needs glucose
continuously as a primary source of energy. Hypoglycemia is the most common biochemical …

Congenital hyperinsulinism (CHI) is a rare genetic disorder characterized by excess insulin
secretion, which results in hypoglycemia. Mutation of sulfonylurea receptor 1 (SUR1) …