PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease
HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …
diseases that increased with aging. With the emergence of aging population, the health …
Targeting Akt in cancer for precision therapy
H Hua, H Zhang, J Chen, J Wang, J Liu… - Journal of Hematology & …, 2021 - Springer
Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …
Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …
The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review
F Rascio, F Spadaccino, MT Rocchetti, G Castellano… - Cancers, 2021 - mdpi.com
Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …
Passive coupling of membrane tension and cell volume during active response of cells to osmosis
During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …
plasma membrane tension that can passively change through osmosis. How tension and …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
Matrine: a promising natural product with various pharmacological activities
H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …
Aiton. At present, a large number of studies have proved that matrine has an anticancer …
Multiple forms of cell death: A focus on the PI3K/AKT pathway
J Xu, Y Li, M Kang, C Chang, H Wei… - Journal of Cellular …, 2023 - Wiley Online Library
Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …
extensive research has shed light on the occurrence, progress, and final outcome of cell …
Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …
available, they are still painful because of their adverse side effects. Available treatments …
[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …