PI3K/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer's disease and Parkinson's disease

HZ Long, Y Cheng, ZW Zhou, HY Luo… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) and Parkinson's disease (PD) are two typical neurodegenerative
diseases that increased with aging. With the emergence of aging population, the health …

Targeting Akt in cancer for precision therapy

H Hua, H Zhang, J Chen, J Wang, J Liu… - Journal of Hematology & …, 2021 - Springer
Biomarkers-guided precision therapeutics has revolutionized the clinical development and
administration of molecular-targeted anticancer agents. Tailored precision cancer therapy …

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

The pathogenic role of PI3K/AKT pathway in cancer onset and drug resistance: an updated review

F Rascio, F Spadaccino, MT Rocchetti, G Castellano… - Cancers, 2021 - mdpi.com
Simple Summary Drug resistance remains one of the major problems in cancer therapy and
is responsible for up to 90% of cancer-related deaths. It exists across all types of cancer and …

Passive coupling of membrane tension and cell volume during active response of cells to osmosis

C Roffay, G Molinard, K Kim… - Proceedings of the …, 2021 - National Acad Sciences
During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …

The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Matrine: a promising natural product with various pharmacological activities

H Zhang, L Chen, X Sun, Q Yang, L Wan… - Frontiers in …, 2020 - frontiersin.org
Matrine is an alkaloid isolated from the traditional Chinese medicine Sophora flavescens
Aiton. At present, a large number of studies have proved that matrine has an anticancer …

Multiple forms of cell death: A focus on the PI3K/AKT pathway

J Xu, Y Li, M Kang, C Chang, H Wei… - Journal of Cellular …, 2023 - Wiley Online Library
Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …

Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach

TA Zughaibi, M Suhail, M Tarique, S Tabrez - International Journal of …, 2021 - mdpi.com
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …

[HTML][HTML] The PI3K-AKT pathway: A plausible therapeutic target in Parkinson's disease

A Goyal, A Agrawal, A Verma, N Dubey - Experimental and Molecular …, 2023 - Elsevier
Parkinson's disease is a common progressive and multifactorial neurodegenerative disease,
characterized by the loss of midbrain dopaminergic neurons. Numerous pathological …