Simple Summary Myelofibrosis is an aggressive bone marrow cancer whose clinical
presentation can be extremely heterogenous. Two distinct phenotypes, myeloproliferative …

The spliceosomal complex components, together with the heterogeneous nuclear
ribonucleoproteins (hnRNPs) and serine/arginine-rich (SR) proteins, regulate the process of …

Serine/arginine-rich splicing factors (SRSFs) refer to twelve RNA-binding proteins which
regulate splice site recognition and spliceosome assembly during precursor messenger …

Dysregulation of innate immune signaling is a hallmark of hematologic malignancies.
Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic …

Background Rare diseases collectively affect up to 10% of the population, but often lack
effective treatment, and typically little is known about their pathophysiology. Major …

The proliferation marker Ki‐67 is widely used within the field of diagnostic histopathology as
a prognostic marker for solid cancers. However, Ki‐67 is hardly used for prognostic and …

Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with
driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic …

Serine-and arginine-rich splicing factors are pivotal modulators of constitutive splicing and
alternative splicing that bind to the cis-acting elements in precursor mRNAs and facilitate the …

Introduction Chronic myelomonocytic leukemia (CMML) is a clonal myeloid neoplasm,
denoted by overlapping myelodysplastic and myeloproliferative features, with poor overall …

Objectives SRSF2 mutations are known to be associated with poor outcomes in
myelodysplastic neoplasm, but studies on their prognostic impact on acute myeloid …