At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

The axon initial segment (AIS) is located at the proximal axon and is the site of action
potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive …

Abstract Since Hodgkin and Huxley discovered the potassium current that underlies the
falling phase of action potentials in the squid giant axon, the diversity of voltage‐gated …

The action potential generally begins in the axon initial segment (AIS), a principle confirmed
by 60 years of research; however, the most recent advances have shown that a very rich …

The axon initial segment (AIS) is positioned between the axonal and somato-dendritic
compartments and plays a pivotal role in triggering action potentials (APs) and determining …

PA (phosphatidic acid) is a lipid second messenger involved in an array of processes
occurring during a plant's life cycle. These include development, metabolism, and both biotic …

The axon initial segment (AIS) is a highly specialized neuronal subregion that is the site of
action potential initiation and the boundary between axonal and somatodendritic …

The axon initial segment (AIS) plays a key role in maintaining the molecular and functional
polarity of the neuron. The relationship between the AIS architecture and the microtubules …

Structural plasticity of the axon initial segment (AIS), the trigger zone of neurons, is a
powerful means for regulating neuronal activity. Here, we show that AIS plasticity is not …

Neurons are polarized cells that have a complex and unique morphology: long processes
(axons and dendrites) extending far from the cell body. In addition, the somatodendritic and …