Microemulsion utility in pharmaceuticals: Implications for multi-drug delivery

SP Callender, JA Mathews, K Kobernyk… - International journal of …, 2017 - Elsevier
Emulsion technology has been utilized extensively in the pharmaceutical industry. This
article presents a comprehensive review of the literature on an important subcategory of …

Targeting oxidative stress in central nervous system disorders

M Patel - Trends in pharmacological sciences, 2016 - cell.com
There is widespread recognition that reactive oxygen species (ROS) play key roles in
normal brain function and pathology in the context of neurological disease. Oxidative stress …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …

A Fluorogenic ONOO-Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage

L Xing, B Wang, J Li, X Guo, X Lu, X Chen… - Journal of the …, 2022 - ACS Publications
Ischemia–reperfusion (I/R) injuries are from the secondary radicals of ONOO–. Direct radical
scavenging is difficult because of their high reactivity. ONOO–is longer-lived than the …

Pharmacological applications of antioxidants: lights and shadows

L Saso, O Firuzi - Current Drug Targets, 2014 - ingentaconnect.com
Oxidative stress is linked with many pathologies ranging from cancer to neurodegenerative
disorders and antioxidants have presumably therapeutic value in such diseases. In this …

Asymmetric nitrone synthesis via ligand-enabled copper-catalyzed cope-type hydroamination of cyclopropene with oxime

Z Li, J Zhao, B Sun, T Zhou, M Liu, S Liu… - Journal of the …, 2017 - ACS Publications
We report realization of the first enantioselective Cope-type hydroamination of oximes for
asymmetric nitrone synthesis. The ligand promoted asymmetric cyclopropene …

The optical nonlinear properties of a new synthesized azo-nitrone compound

DZ Mutlaq, QMA Hassan, HA Sultan, CA Emshary - Optical Materials, 2021 - Elsevier
In this article the preparation of compound heterogeneous azo-nitrone is introduced. Novel
compound resulted via the reaction between azoaldehyde and N-phenylhydroxylamine …

NO and HNO donors, nitrones, and nitroxides: Past, present, and future

C Oliveira, S Benfeito, C Fernandes… - Medicinal research …, 2018 - Wiley Online Library
The biological effects attributed to nitric oxide (• NO) and nitroxyl (HNO) have been
extensively studied, propelling their array of putative clinical applications beyond …

Recent advances on Nitrones Design for Stroke Treatment: Miniperspective

J Marco-Contelles - Journal of Medicinal Chemistry, 2020 - ACS Publications
The recent advances of tetramethylpyrazine nitrones and quinolylnitrones for the treatment
of stroke have been reviewed and compared with other agents, showing promising …

Conferring Phosphorogenic Properties on Iridium (III)‐Based Bioorthogonal Probes through Modification with a Nitrone Unit

LCC Lee, JCW Lau, HW Liu… - Angewandte Chemie …, 2016 - Wiley Online Library
The use of bioorthogonal probes that display fluorogenic or phosphorogenic properties is
advantageous to the labeling and imaging of biomolecules in live cells and organisms …