[HTML][HTML] Understanding retroviral life cycle and its genomic RNA packaging
Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …
obligate parasites, their replication involves a series of steps during which the virus hijacks …
Advances in HIV-1 assembly
G Lerner, N Weaver, B Anokhin, P Spearman - Viruses, 2022 - mdpi.com
The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the
plasma membrane of infected cells. An abundance of recent discoveries has advanced our …
plasma membrane of infected cells. An abundance of recent discoveries has advanced our …
Short-and long-range interactions in the HIV-1 5′ UTR regulate genome dimerization and packaging
RNA dimerization is the noncovalent association of two human immunodeficiency virus-1
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
(HIV-1) genomes. It is a conserved step in the HIV-1 life cycle and assumed to be a …
Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation
HIV-1 transcript function is controlled in part by twinned transcriptional start site usage,
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …
Selective packaging of HIV-1 RNA genome is guided by the stability of 5′ untranslated region polyA stem
OA Nikolaitchik, S Liu, JP Kitzrow… - Proceedings of the …, 2021 - National Acad Sciences
To generate infectious virus, HIV-1 must package two copies of its full-length RNA into
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …
particles. HIV-1 transcription initiates from multiple, neighboring sites, generating RNA …
Dynamic nanopore long-read sequencing analysis of HIV-1 splicing events during the early steps of infection
N Nguyen Quang, S Goudey, E Ségéral, A Mohammad… - Retrovirology, 2020 - Springer
Background Alternative splicing is a key step in Human Immunodeficiency Virus type 1 (HIV-
1) replication that is tightly regulated both temporally and spatially. More than 50 different …
1) replication that is tightly regulated both temporally and spatially. More than 50 different …
A purine loop and the primer binding site are critical for the selective encapsidation of mouse mammary tumor virus genomic RNA by Pr77Gag
A Chameettachal, V Vivet-Boudou… - Nucleic acids …, 2021 - academic.oup.com
Retroviral RNA genome (gRNA) harbors cis-acting sequences that facilitate its specific
packaging from a pool of other viral and cellular RNAs by binding with high-affinity to the …
packaging from a pool of other viral and cellular RNAs by binding with high-affinity to the …
Structural maturation of the HIV-1 RNA 5' untranslated region by Pr55Gag and its maturation products
O Gilmer, E Mailler, JC Paillart, A Mouhand, C Tisné… - RNA biology, 2022 - Taylor & Francis
Maturation of the HIV-1 viral particles shortly after budding is required for infectivity. During
this process, the Pr55Gag precursor undergoes a cascade of proteolytic cleavages, and …
this process, the Pr55Gag precursor undergoes a cascade of proteolytic cleavages, and …
MMTV RNA packaging requires an extended long-range interaction for productive Gag binding to packaging signals
SG Prabhu, VN Pillai, LM Ali, V Vivet-Boudou… - PLoS …, 2024 - journals.plos.org
The packaging of genomic RNA (gRNA) into retroviral particles relies on the specific
recognition by the Gag precursor of packaging signals (Psi), which maintain a complex …
recognition by the Gag precursor of packaging signals (Psi), which maintain a complex …
[HTML][HTML] Genome sequence analysis suggests coevolution of the DIS, SD, and Psi hairpins in HIV-1 genomes
HIV-1 RNA dimerization is a critical step in viral life cycle. It is a prerequisite for genome
packaging and plays an important role in reverse transcription and recombination …
packaging and plays an important role in reverse transcription and recombination …