Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
From carbohydrate leads to glycomimetic drugs
B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …
and as structural building blocks, they are fundamental constituents of every cell surface …
Functional diversification of IgGs through Fc glycosylation
TT Wang, JV Ravetch - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
IgG antibodies are secreted from B cells and bind to a variety of pathogens to control
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …
The relationship between leishmaniasis and AIDS: the second 10 years
J Alvar, P Aparicio, A Aseffa, M Den Boer… - Clinical microbiology …, 2008 - Am Soc Microbiol
To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases
reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of …
reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of …
DC-SIGN: escape mechanism for pathogens
Y van Kooyk, TBH Geijtenbeek - Nature Reviews Immunology, 2003 - nature.com
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are
recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on …
recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on …
Prospecting human milk oligosaccharides as a defense against viral infections
RE Moore, LL Xu, SD Townsend - ACS infectious diseases, 2021 - ACS Publications
In addition to providing maximal nutritional value for neonatal growth and development,
human milk functions as an early defense mechanism against invading pathogens. Human …
human milk functions as an early defense mechanism against invading pathogens. Human …
Recruitment of HIV and its receptors to dendritic cell-T cell junctions
D McDonald, L Wu, SM Bohks, VN KewalRamani… - Science, 2003 - science.org
Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity
without themselves becoming infected. Using live-cell microscopy, we found that HIV was …
without themselves becoming infected. Using live-cell microscopy, we found that HIV was …
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
Leprosy enables investigation of mechanisms by which the innate immune system
contributes to host defense against infection, because in one form, the disease progresses …
contributes to host defense against infection, because in one form, the disease progresses …
Self-and nonself-recognition by C-type lectins on dendritic cells
TBH Geijtenbeek, SJ van Vliet, A Engering… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that
collect antigen in body tissues and transport them to draining lymph nodes. Antigenic …
collect antigen in body tissues and transport them to draining lymph nodes. Antigenic …
How C‐type lectins detect pathogens
Glycosylation of proteins has proven extremely important in a variety of cellular processes,
including enzyme trafficking, tissue homing and immune functions. In the past decade …
including enzyme trafficking, tissue homing and immune functions. In the past decade …