Glycomimetics for the inhibition and modulation of lectins

S Leusmann, P Ménová, E Shanin, A Titz… - Chemical Society …, 2023 - pubs.rsc.org
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …

From carbohydrate leads to glycomimetic drugs

B Ernst, JL Magnani - Nature reviews Drug discovery, 2009 - nature.com
Carbohydrates are the most abundant natural products. Besides their role in metabolism
and as structural building blocks, they are fundamental constituents of every cell surface …

Functional diversification of IgGs through Fc glycosylation

TT Wang, JV Ravetch - The Journal of clinical investigation, 2019 - Am Soc Clin Investig
IgG antibodies are secreted from B cells and bind to a variety of pathogens to control
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …

The relationship between leishmaniasis and AIDS: the second 10 years

J Alvar, P Aparicio, A Aseffa, M Den Boer… - Clinical microbiology …, 2008 - Am Soc Microbiol
To date, most Leishmania and human immunodeficiency virus (HIV) coinfection cases
reported to WHO come from Southern Europe. Up to the year 2001, nearly 2,000 cases of …

DC-SIGN: escape mechanism for pathogens

Y van Kooyk, TBH Geijtenbeek - Nature Reviews Immunology, 2003 - nature.com
Dendritic cells (DCs) are crucial in the defence against pathogens. Invading pathogens are
recognized by Toll-like receptors (TLRs) and receptors such as C-type lectins expressed on …

Prospecting human milk oligosaccharides as a defense against viral infections

RE Moore, LL Xu, SD Townsend - ACS infectious diseases, 2021 - ACS Publications
In addition to providing maximal nutritional value for neonatal growth and development,
human milk functions as an early defense mechanism against invading pathogens. Human …

Recruitment of HIV and its receptors to dendritic cell-T cell junctions

D McDonald, L Wu, SM Bohks, VN KewalRamani… - Science, 2003 - science.org
Monocyte-derived dendritic cells (MDDCs) can efficiently bind and transfer HIV infectivity
without themselves becoming infected. Using live-cell microscopy, we found that HIV was …

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

SR Krutzik, B Tan, H Li, MT Ochoa, PT Liu… - Nature medicine, 2005 - nature.com
Leprosy enables investigation of mechanisms by which the innate immune system
contributes to host defense against infection, because in one form, the disease progresses …

Self-and nonself-recognition by C-type lectins on dendritic cells

TBH Geijtenbeek, SJ van Vliet, A Engering… - Annu. Rev …, 2004 - annualreviews.org
▪ Abstract Dendritic cells (DCs) are highly efficient antigen-presenting cells (APCs) that
collect antigen in body tissues and transport them to draining lymph nodes. Antigenic …

How C‐type lectins detect pathogens

A Cambi, M Koopman, CG Figdor - Cellular microbiology, 2005 - Wiley Online Library
Glycosylation of proteins has proven extremely important in a variety of cellular processes,
including enzyme trafficking, tissue homing and immune functions. In the past decade …