UniProt tools: BLAST, align, peptide search, and ID mapping

R Zaru, S Orchard, UniProt Consortium - Current protocols, 2023 - Wiley Online Library
Abstract The Universal Protein Resource (UniProt) is a comprehensive resource for protein
sequence and annotation data (UniProt Consortium, 2023). The UniProt website receives …

PRALINE: a multiple sequence alignment toolbox that integrates homology-extended and secondary structure information

VA Simossis, J Heringa - Nucleic acids research, 2005 - academic.oup.com
PRofile ALIgNEment (PRALINE) is a fully customizable multiple sequence alignment
application. In addition to a number of available alignment strategies, PRALINE can …

UniProt tools

S Pundir, MJ Martin, C O'Donovan… - Current protocols in …, 2016 - Wiley Online Library
Abstract The Universal Protein Resource (UniProt) is a comprehensive resource for protein
sequence and annotation data (UniProt Consortium, 2015). The UniProt Web site receives∼ …

Integrating protein secondary structure prediction and multiple sequence alignment

VA Simossis, J Heringa - Current Protein and Peptide Science, 2004 - ingentaconnect.com
Modern protein secondary structure prediction methods are based on exploiting
evolutionary information contained in multiple sequence alignments. Critical steps in the …

Designing new β-lactams: implications from their targets, resistance factors and synthesizing enzymes

KS Goo, TS Sim - Current Computer-Aided Drug Design, 2011 - ingentaconnect.com
Penicillins and cephalosporins are β-lactam antibiotics widely used to treat bacterial
infectious diseases. They mainly target the cell wall biosynthesis pathway to inhibit bacterial …

Geometricus represents protein structures as shape-mers derived from moment invariants

J Durairaj, M Akdel, D de Ridder, ADJ van Dijk - Bioinformatics, 2020 - academic.oup.com
Motivation As the number of experimentally solved protein structures rises, it becomes
increasingly appealing to use structural information for predictive tasks involving proteins …

In silico environmental sampling of emerging fungal pathogens via big data analysis

L Irinyi, M Roper, R Malik, W Meyer - Fungal Ecology, 2023 - Elsevier
Yeast species in the Candida haemulonii complex (C. haemulonii, C. haemulonii var.
vulnera, C. duobushaemulonii, C. pseudohaemulonii, and C. vulturna) and closely related …

The PRALINE online server: optimising progressive multiple alignment on the web

VA Simossis, J Heringa - 2003 - Elsevier
We introduce the online server for PRALINE (http://ibium. cs. vu. nl/programs/pralinewww/),
an iterative versatile progressive multiple sequence alignment (MSA) tool. PRALINE …

Strategies for increasing protein stability

PG Chandler, SS Broendum, BT Riley… - Protein Nanotechnology …, 2020 - Springer
The stability of wild-type proteins is often a hurdle to their practical use in research, industry,
and medicine. The route to engineering stability of a protein of interest lies largely with the …

Revolutionizing genomics with reinforcement learning techniques

M Karami, R Alizadehsani, A Argha, I Dehzangi… - arXiv preprint arXiv …, 2023 - arxiv.org
In recent years, Reinforcement Learning (RL) has emerged as a powerful tool for solving a
wide range of problems, including decision-making and genomics. The exponential growth …