As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Both the innate and adaptive immune systems decline with age, causing greater
susceptibility to infectious diseases and reduced responses to vaccination. Diseases are …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

The immune systems of men and women differ in significant ways, especially after puberty.
In particular, females are generally more prone to autoimmunity, but experience lower rates …

There are many age-associated changes in the respiratory and pulmonary immune system.
These changes include decreases in the volume of the thoracic cavity, reduced lung …

We evaluated TLR function in primary human dendritic cells (DCs) from 104 young (age 21–
30 y) and older (≥ 65 y) individuals. We used multicolor flow cytometry and intracellular …

The immune system of an organism is an essential component of the defense mechanism
aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed …

Lung aging is associated with structural remodeling, a decline of respiratory function and a
higher susceptibility to acute and chronic lung diseases. Individual factors that modulate …

Advanced age is associated with alterations in innate and adaptive immune responses,
which contribute to an increased risk of infection in elderly patients. Coupled with this …

Aging affects every innate immune cell, including changes in cell numbers and function.
Defects in the function of some cells are intrinsic, whereas for other cells, defects are …