Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Background While the underlying causes of cancer are genetic modifications, changes in
cellular states mediate cancer development. Tumor cells display markedly changed …

Depression is a common condition, but current treatments are only effective in a subset of
individuals. To identify new treatment targets, we integrated depression genome-wide …

Chemical biology has revealed the importance of sialic acids as a major signal in physiology
and disease. The terminal modification α-2, 6-sialic acid is controlled by the enzymes …

N-glycan, a fundamental and versatile protein modification in mammals, plays critical roles
in various physiological and pathological events including cancer progression. The …

N-glycosylation is a frequent modification of proteins, essential for all domains of life. N-
glycan biosynthesis is a dynamic, complex, non-templated process, wherein specific …

Brain metastasis (BM) predominantly occurs in triple-negative (TN) and epidermal growth
factor 2 (HER2)-positive breast cancer (BC) patients, and currently, there is an unmet need …

Abstract Human Milk Oligosaccharides (HMOs) are abundant carbohydrates fundamental to
infant health and development. Although these oligosaccharides were discovered more than …

Characteristically, cells must sense and respond to environmental cues. Despite the
importance of cell–cell communication, our understanding remains limited and often lacks …

Highlights•Glycosylation is regulated at the transcriptional, translational and post-
translational levels.•Advances in sequencing and structural analysis enable data collection …