Actin dynamics in cell motility, division, and phagocytosis is regulated by complex factors
with multiple feedback loops, often leading to emergent dynamic patterns in the form of …

Tumor progression, including metastasis, is significantly influenced by factors in the tumor
microenvironment (TME) such as mechanical force, shear stress, chemotaxis, and hypoxia …

Much of current understanding of cell motility arose from studying steady treadmilling of actin
arrays. Recently, there have been a growing number of observations of a more complex …

Cells in vivo reside within complex microenvironments composed of both biochemical and
biophysical cues. The dynamic feedback between cells and their microenvironments hinges …

Cells construct a number of plasma membrane structures to meet a range of physiological
demands. Driven by juxtamembrane actin machinery, these actin-based membrane …

Alternative splicing of proteins gives rise to different isoforms that play a crucial role in
regulating several cellular processes. Notably, splicing profiles are altered in several cancer …

Dynamic actin networks are excitable. In migrating cells, feedback loops can amplify
stochastic fluctuations in actin dynamics, often resulting in traveling waves of protrusion. The …

Numerous experimental studies have established that cells can sense the stiffness of
underlying substrates and have quantified the effect of substrate stiffness on stress fibre …

During macropinocytosis, cells remodel their morphologies for the uptake of extracellular
matter. This endocytotic mechanism relies on the collapse and closure of precursory …

In murine mammary epithelial cancer cells, galectin-3 binding to β1, 6-
acetylglucosaminyltransferase V (Mgat5)–modified N-glycans restricts epidermal growth …