Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Gastric and esophageal cancers are as main cancers of the gastrointestinal (GI) tract, which
are associated with poor diagnosis and survival. Several efforts were made in the past few …

Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

The risk of cancer and associated mortality increases substantially in humans from the age
of 65 years onwards,,,,–. Nonetheless, our understanding of the complex relationship …

TGF-β signaling can be pro-tumorigenic or tumor suppressive. We investigated this duality in
pancreatic ductal adenocarcinoma (PDA), which, with other gastrointestinal cancers …

Cancer immunotherapy shows limited efficacy against many solid tumors that originate from
epithelial tissues, including triple-negative breast cancer (TNBC). We identify the SOX4 …

Background Several of the thousands of human long noncoding RNAs (lncRNAs) have
been functionally characterized, yet their potential involvement in hepatocellular carcinoma …

A lack of relevant genetic models and cell lines hampers our understanding of
hepatoblastoma pathogenesis and the development of new therapies for this neoplasm …

Sex-determining region Y-related (SRY) high-mobility group box 4 (SOX4) is a member of
the group C subfamily of SOX transcription factors and promotes tumorigenesis by endowing …

Cutaneous melanoma (CM) represents one of the most metastasizing and drug resistant
solid tumors. CM is characterized by a remarkable metabolic plasticity and an important …