Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions

M Gaba, C Mohan - Medicinal Chemistry Research, 2016 - Springer
Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles,
which are widely explored and utilized by the pharmaceutical industry for drug discovery …

Structure–activity relationship analysis of benzimidazoles as emerging anti-inflammatory agents: An overview

R Veerasamy, A Roy, R Karunakaran, H Rajak - Pharmaceuticals, 2021 - mdpi.com
A significant number of the anti-inflammatory drugs currently in use are becoming obsolete.
These are exceptionally hazardous for long-term use because of their possible unfavourable …

Benzimidazole: an emerging scaffold for analgesic and anti-inflammatory agents

M Gaba, S Singh, C Mohan - European journal of medicinal chemistry, 2014 - Elsevier
Within the vast range of heterocycles, benzimidazole and its derivatives are found to be
trendy structures employed for discovery of drugs in the field of pharmaceutical and …

Benzimidazole based derivatives as anticancer agents: Structure activity relationship analysis for various targets

G Satija, B Sharma, A Madan, A Iqubal… - Journal of …, 2022 - Wiley Online Library
Benzimidazole, the benzo derivative of imidazole, is a class of bicyclic aromatic organic
compound consisting of six‐membered benzene ring fused to five‐membered imidazole at 4 …

Benzimidazole: A milestone in the field of medicinal chemistry

MS Vasava, MN Bhoi, SK Rathwa… - Mini reviews in …, 2020 - ingentaconnect.com
In the last 2-3 decades, the broad research in the application of benzimidazole derivatives
made it important for mankind. Many scientists have worked on benzimidazole derivatives …

Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine

OO Ajani, DV Aderohunmu, CO Ikpo… - Archiv der …, 2016 - Wiley Online Library
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …

Benzimidazole-core as an antimycobacterial agent

RS Keri, CK Rajappa, SA Patil, BM Nagaraja - Pharmacological Reports, 2016 - Elsevier
Mycobacterium tuberculosis (Mtb) is considered as one of the precarious bacterial infections
around the world. Through a projected 8.7 million new tuberculosis (TB) cases and 1.4 …

Visible‐light‐promoted synthesis of Benzimidazoles

S Park, J Jung, EJ Cho - European Journal of Organic …, 2014 - Wiley Online Library
A simple and environmentally‐friendly synthetic method for benzimidazoles, which are
important structural motifs in many applications owing to their various biological functions …

Synthesis and antimicrobial activity of some heterocyclic compounds bearing benzimidazole and pyrazoline motifs

NC Desai, D Pandya, D Vaja - Medicinal Chemistry Research, 2018 - Springer
Abstract A series of 1-(3-(1 H-benzoimidazol-2-yl)-5-aryl-4-5dihydro-1 H-pyrazol-1-yl)-2-
(napthalene-1-yloxy) ethanones (5a–l) are synthesized and evaluated their antimicrobial …

Ruthenium-catalyzed benzimidazoisoquinoline synthesis via oxidative coupling of 2-arylbenzimidazoles with alkynes

N Kavitha, G Sukumar, VP Kumar, PS Mainkar… - Tetrahedron …, 2013 - Elsevier
Synthesis of a fused bis-heterocyclic framework, benzimidazoisoquinoline, has been
achieved using Ru-catalyzed reaction of alkynes with 2-aryl benzimidazoles in the presence …