Amiloride inhibits most plasma membrane Na+ transport systems. We have reviewed the
pharmacology of inhibition of these transporters by amiloride and its analogs. Thorough …

The'pump and leak" model of catioi~ transport was formally proposed by Tostesun and
Hoffman [l] in 1960 to explain the maintenance of cellular volume in animal cells. Over the …

Looked at from the genetic point-of-view cancer represents a daunting and, frankly,
confusing multiplicity of diseases (at least 100) that require an equally large variety of …

It has been shown that short-term (hours) treatment with β-adrenergic agonists can stimulate
lung liquid clearance via augmented Na+ transport across alveolar epithelial cells. This …

Aside from the normal, sporadic turnover of epithelial cells along the adult nephron, most
somatic cells in the kidney do not divide, or if they are obligated to respond to an external …

Ying-xin Zhuang, Edward J. Cragoe, Jr., Ted Shaikewitz, Luis Glaser,* and Dan Cassel*
abstract: Na+/H+ exchange is stimulated in a variety of cell types by addition of mitogenic …

Addition of amiloride to A431 human epidermoid carcinoma cell membranes inhibited
autophosphorylation of the epidermal growth factor (EGF) receptor. The tyrosine …

We prepared proton-transporting membrane vesicles from the avian osteoclast's ruffled
membrane, a specialized region of the cell surface that acidifies the bone resorption space …

Since the mechanism underlying the insulin stimulation of (Na+, K+)-ATPase transport
activity observed in multiple tissues has remained undetermined, we have examined (Na+ …

A significant body of circumstantial evidence suggests that Ca 2+ and calmodulin are
important regulators of cell growth and malignant transformation. The case for such a role is …