The role of adipokines in health and disease

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

Advances in research on type 2 diabetes mellitus targets and therapeutic agents

J Su, Y Luo, S Hu, L Tang, S Ouyang - International Journal of Molecular …, 2023 - mdpi.com
Diabetes mellitus is a chronic multifaceted disease with multiple potential complications, the
treatment of which can only delay and prolong the terminal stage of the disease, ie, type 2 …

Adipose–Muscle crosstalk in age-related metabolic disorders: The emerging roles of adipo-myokines

P Fang, Y She, M Yu, W Min, W Shang… - Ageing Research Reviews, 2023 - Elsevier
Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

The role of adipokines in inflammatory mechanisms of obesity

TV Kirichenko, YV Markina, AI Bogatyreva… - International Journal of …, 2022 - mdpi.com
Adipokines are currently widely studied cellular signaling proteins produced by adipose
tissue and involved in various processes, including inflammation; energy and appetite …

Estrogens in adipose tissue physiology and obesity-related dysfunction

A Kuryłowicz - Biomedicines, 2023 - mdpi.com
Menopause-related decline in estrogen levels is accompanied by a change in adipose
tissue distribution from a gynoid to an android and an increased prevalence of obesity in …

The neutrophil to lymphocyte ratio (NLR) positively correlates with the presence and severity of metabolic syndrome in obese adults, but not in obese children …

A Marra, A Bondesan, D Caroli, G Grugni… - BMC Endocrine …, 2023 - Springer
Metabolic syndrome (MetS) associated with obesity is a pathological condition increasing
worldwide. Recent studies have demonstrated that the neutrophil to lymphocyte ratio (NLR) …

Regulatory mechanisms of macrophage polarization in adipose tissue

D Pan, G Li, C Jiang, J Hu, X Hu - Frontiers in Immunology, 2023 - frontiersin.org
In adipose tissue, macrophages are the most abundant immune cells with high
heterogeneity and plasticity. Depending on environmental cues and molecular mediators …

Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases

T Suzuki, T Ohishi, H Tanabe, N Miyoshi, Y Nakamura - Molecules, 2023 - mdpi.com
Matrix metalloproteinases (MMPs) are zinc-dependent metalloproteinases that play
important roles in a variety of diseases, including cancer, cardiovascular disease, diabetes …

Frontiers and hotspots of adipose tissue and NAFLD: a bibliometric analysis from 2002 to 2022

S Gu, Y Qiao, S Liu, S Yang, S Cong, S Wang… - Frontiers in …, 2023 - frontiersin.org
Background: The annual incidence of non-alcoholic fatty liver disease (NAFLD) continues to
rise steadily. In recent years, adipose tissue (AT) has gained recognition as a pivotal …

Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines

J Valencia-Ortega, JM Solis-Paredes… - International Journal of …, 2023 - mdpi.com
There is a high frequency of overweight and obesity in women of reproductive age. Women
who start pregnancy with overweight or obesity have an increased risk of developing …